Analysis of glutathione: implication in redox and detoxification.

By A. Pastore, G. Federici, E. Bertini, F. Piemonte. Clinica chimica acta; international journal of clinical chemistry, 2003

1,150 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a3d8f2e7ed48a0e621f20d9dfcdc52d58915ea8f

How researchers see this paper

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In Biochemistry

1. Isabel C. F. R. Ferreira
2. L. Barros
3. Rui M. V. Abreu
4. I. Dalle-Donne
5. A. Milzani
6. I. Peluso
7. R. Rossi
8. M. Valko

In Molecular Biology

1. Isabel C. F. R. Ferreira
2. M. Valko
3. E. Kurutaş
4. L. Barros
5. I. Dalle-Donne
6. A. Milzani
7. I. Peluso
8. R. Rossi

Citations in the corpus

• The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “Depletion of total GSH (GSH + 2 GSSG + protein-bound glutathione) and a decreased GSH:GSSG ratio are indicators of oxidative stress in ischemic brain disease, cardiovascular diseases, and cancer, and decreased concentrations of GSH are consistently observed in both types of diabetes mellitus [155–15”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “A large number of studies have established an association between cancer incidence and various disorders of GSH-related enzyme functions, alterations of glutathione S-transferases (GSTs) being most frequently reported (Pastore et al., 2003).”
• Biomarkers of oxidative damage in human disease. (2006, background): “Cardiovascular disease (57) Cataract genesis (90)”
• Antioxidants in wild mushrooms. (2009, background): “The capacity of GSH to regenerate the most important antioxidant molecules is linked with the redox state of the glutathione disulphide/glutathione (GSSG/GSH) couple [33].”
• Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006, background): “…enzyme activity [Klatt and Lamas, 2000], cell membrane integrity and signal transduction [Dickinson and Forman, 2002; Sagristá et al., 2002], transcription factor binding and gene expression [Deplancke and Gaskins, 2002], phase II detoxification [Pastore et al., 2003], and apoptosis [Hall, 1999].”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “…to enhance brain GSH levels include the administration of lipophilic GSH-derivatives or precursors , the administration of drugs to induce GSH biosynthetic enzymes or to inhibit g-glutamyl transpeptidase (and thus inhibit GSH degradation), and/or the administration of GSH export inhibitors.”
• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “Upregulation of this process provides an additional mechanism for GSH maintenance in the cell.”
• Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (2017, methodology): “Several methods have been used to determine the GSH in biological samples (spectrophotometry, HPLC, capillary electrophoresis, nuclear magnetic resonance, and mass spectrometry) [307].”
• Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “Moreover, GSH in the nucleus involves in mechanisms that are necessary for DNA repair and expression [18].”