Early expression of angiogenesis factors in acute myocardial ischemia and infarction.

By S. Lee, P. Wolf, Ryan Escudero, R. Deutsch, S. Jamieson, P. Thistlethwaite. New England Journal of Medicine, 2000

757 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/a24097747f5bb40cce2e66c9cb53656e1cc215b7

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Citations in the corpus

ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “HIF-1 mRNA levels increase dramatically in response to hypoxia or ischemia in brain, heart, kidney, lungs, and skeletal muscle (15, 23, 189, 351, 369).”
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, result): “However, VEGF is also expressed in the ischemic area without EPC incorporation, which is in accordance to previous findings [33].”
Hypoxia-Inducible Factor-1 (HIF-1) (2006, neutral): “For example, the levels of HIF-1 and VEGF were increased in the myocardium when patients developed acute coronary artery occlusion (Lee et al., 2000).”
Oxygen, oxidative stress, hypoxia, and heart failure. (2005, background): “HIF-1α levels have been shown to be elevated in the myocardium of patients with ischemic cardiomyopathy (120), and it is conceivable that chronic transcriptional activation of HIF-1α–responsive genes is deleterious.”
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. (2001, background): “Nuclear accumulation of the protein can be detected immunohistochemically and has been shown to occur not only in human malignancies and their metastases (16–19) but also in ischemic myocardial tissue (20).”
Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “the chemoattractants for neoangiogenesis (46), it was logical to test”
Regulation of angiogenesis by hypoxia: role of the HIF system (2003, background): “Levels are substantially increased after systemic hypoxia or tissue ischemia, although the extent and time course of induction varies between tissue”
Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “The disruption of the paracrine relationship between tumor and endothelium by VEGFR-2 antagonists enhances the vasculitic effects of ionizing radiation (Lee et al., 2000a; Geng et al., 2001).”
HIF-1 and human disease: one highly involved factor. (2000, background): “HIF-1 mRNA and protein expression are induced and precede VEGF expression during acute ischemia and early infarction in the human heart (Lee et al. 2000).”