Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

By D. Aebersold, P. Burri, K. Beer, J. Laissue, V. Djonov, R. Greiner, G. Semenza. Cancer Research, 2001

671 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cb26d88c003847d89c8ec3dfb79abbd04b557925

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Citations in the corpus

• 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. (2003, background): “HIFneck cancers (Aebersold et al., 2001; Beasley et al., 2002; Birner et al., 2000, 2001; Blancher et al., 2000; Bos et al., 2001; Giatro- 1␣ is rapidly degraded by the proteasome under normoxic conditions.”
• Hypoxia in cancer: significance and impact on clinical outcome (2007, background): “Importantly, these differences cannot be entirely ascribed to the wellknown existence of a “hypoxia-independent” or “diffuse” staining pattern for HIF-1! [40, 42] which is commonly attributed to oncogene- or growth factor-mediated HIF-1! expression, being independent of local oxygen concentrations.”
• Defining the Role of Hypoxia-Inducible Factor 1 in Cancer Biology and Therapeutics (2009, unknown): “…Lung, NSCLCd Giatromanolaki et al. (2001) Malignant melanomad Giatromanolaki et al. (2003) Oligodendroglioma Birner et al. (2001a) Oropharynx SCC Aebersold et al. (2001) Ovariana Birner et al. (2001b) Ovarian, serous Daponte et al. (2008) Pancreatic Sun et al. (2007) Prostatee Nanni et al.…”
• The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “with oropharyngeal cancer demonstrating high expression of HIF-1α had a lower chance to achieve complete remission after irradiation.(103) In addition, irradiation was”
• Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α (2009, background): “The presence of HIFs has been associated with poor outcome in a variety of different neoplasms (Birner et al., 2000; Aebersold et al., 2001; Semenza, 2003; Shimogai et al., 2008; Li et al., 2009).”
• Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, background): “Likewise, HIF-1a expression has been correlated with poor outcomes in patients with oropharyngeal cancers (Aebersold et al. 2001), and ovarian cancer patients with high levels of HIF-1a expression and p53 mutations exhibit little or no apoptosis and poorer outcomes (Birner et al. 2001).”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “HIF overexpression in clinical samples is associated with therapeutic resistance or decreased survival following IR or chemotherapy (Aebersold et al., 2001; Birner et al., 2001b; Koukourakis et al., 2002; Burri et al., 2003; Generali et al., 2006; Vergis et al., 2008).”