Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.

By C. Kollman, C. W. Howe, C. Anasetti, J. Antin, S. M. Davies, A. Filipovich, J. Hegland, N. Kamani, N. Kernan, R. King and 3 more. Blood, 2001

712 citations recorded by the source corpus.

Subfields: Epidemiology, Hematology, Surgery

View Paper: https://www.semanticscholar.org/paper/112dabffe1c5c962ab89d0c1535ddd6a1d1b0400

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jesús Gil
2. Ergun Sahin
3. Domhnall McHugh
4. R. DePinho

In Hematology

1. Derrick J. Rossi
2. Irving L. Weissman
3. W. Pang
4. Isabel Beerman

In Surgery

1. N. Sharpless

Citations in the corpus

• How stem cells age and why this makes us grow old (2007, background): “Particularly telling is the clinical observation that increased donor age in bone marrow transplantation is a predictor of transplant-related mortalit”
• Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010, positive): “Most notably, retrospective analysis of bone marrow transplantations in patients has established that donor age is the only parameter significantly associated with survival of the transplant recipients, and this evidence is consistent with a cell-autonomous compromise in the function of haematopoiet”
• Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “For example, HSCs display a decreased success rate of transplantation when isolated from elderly patients (Kollman et al., 2001).”
• High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. (2007, neutral): “1988 to 1989 44 (2) 19 (2) 17 (3) 18 (5) 1990 to 1994 432 (24) 224 (23) 182 (29) 140 (35) 1995 to 1999 787 (43) 441 (45) 292 (46) 176 (44) 2000 to 2003 577 (31) 301 (30) 142 (22) 65 (16) Median follow-up of survivors, mo 73 (3-194) [671] 63 (6-191) [297] 84 (11-192) [134] 96 (4-183) [75]”
• Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age (2011, background): “Clinically, in the setting of bone marrow transplantation, increasing donor age correlates with increasing transplant-related mortality (29).”