Endocrine Disrupting Chemicals and Disease Susceptibility

By T. Schug, Amanda Janesick, B. Blumberg, J. Heindel. Journal of Steroid Biochemistry and Molecular Biology, 2011

1,052 citations recorded by the source corpus.

Environmental chemicals have significant impacts on biological systems. Chemical exposures during early stages of development can disrupt normal patterns of development and thus dramatically alter disease susceptibility later in life. Endocrine disrupting chemicals (EDCs) interfere with the body's endocrine system and produce adverse developmental, reproductive, neurological, cardiovascular, metabolic and immune effects in humans. A wide range of substances, both natural and man-made, are thought to cause endocrine disruption, including pharmaceuticals, dioxin and dioxin-like compounds, polychlorinated biphenyls, DDT and other pesticides, and components of plastics such as bisphenol A (BPA) and phthalates. EDCs are found in many everyday products– including plastic bottles, metal food cans, detergents, flame retardants, food additives, toys, cosmetics, and pesticides. EDCs interfere with the synthesis, secretion, transport, activity, or elimination of natural hormones. This interference can block or mimic hormone action, causing a wide range of effects. This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling. It also includes brief overviews of select disease endpoints associated with endocrine disruption.

Subfields: Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/1574a5bc285c64a91d88a0ce88cba5aab0baaabe

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In Health, Toxicology and Mutagenesis

1. A. Proto
2. P. Bianco
3. Luigi Montano
4. J. Heindel
5. M. Ricciardi
6. C. Pironti
7. O. Motta

Citations in the corpus

• Developmental origins of non-communicable disease: Implications for research and public health (2012, background): “However, it cannot provide an extensive list of references from this burgeoning field and refers only to selected review articles [1-6,8].”
• Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure (2021, background): “or activate hormone receptors; antagonize hormone receptors; alter hormone synthesis, receptor expression, transport across cell membranes, distribution levels and metabolism of hormones and signal transduction in hormone-responsive cells; induce epigenetic modifications in hormone-producing or horm”