Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

By A. Uezumi, So-ichiro Fukada, N. Yamamoto, S. Takeda, K. Tsuchida. Nature Cell Biology, 2010

1,215 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/5d4acddbc7f2787b99accb1ed686df3f8d7eb375

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Citations in the corpus

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle (2011, background): “Similar to the results of cultures of PDGFRa+ cells derived from intact skeletal muscle (Uezumi et al., 2010), only the PDGFRa+ cells differentiated into adipocytes (Fig.”
Aberrant repair and fibrosis development in skeletal muscle (2011, background): “Whether FAP conversion also occurs during aging, and whether Basal lamina ECM deposition Satellite cell Fibro/adipogenic progenitor Resident macrophage Fibroblast Increased number of fibroblasts Fibrogenic-converted myogenic cells Myofiber Atrophic myofiber Young Old Figure 5 Myofiber growth and ext”
Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling (2011, background): “In addition, adipocyte precursor cells have also been found within skeletal muscle and may signal to muscle precursor cells to promote muscle differentiation (Joe et al., 2010; Uezumi et al., 2010).”
Intermuscular Fat: A Review of the Consequences and Causes (2014, background): “Studies investigating the cellular origins of IMAT [102, 103] are attempting to determine the cellular processes that precipitate increased IMAT.”
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “Furthermore, cellcell interactions play an important role in forming this tissue as multipotent fibroblastic/adipogenic mesenchymal progenitors (FAPs) interact with satellite cells to regulate muscle homeostasis (Joe et al., 2010; Uezumi et al., 2010), and endothelial cells were reported to affect s”
Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Similar to skin and heart muscle, which we discuss below, skeletal muscle fibroblasts with progenitor properties express Sca1 (Joe et al., 2010; Uezumi et al., 2010) and, similar to lungs and heart, Gli1 (Kramann et al.”
Structure and Function of the Skeletal Muscle Extracellular Matrix (2011, positive): “Uezumi and colleagues identified a PDGFRaþ progenitor cell population distinct from satellite cells that can differentiate into adipose tissue in vivo under nonregenerating conditions.(135) Interestingly, these cells were observed more in perimysium than endomysium, consistent with the idea that fat”
Adipose tissue plasticity in health and disease (2022, background): “PDGFR a was ﬁrst identiﬁed as a marker of adipogenic cells in regenerating muscle (Joe et al., 2010; Uezumi et al., 2010).”
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, positive): “Several groups have isolated distinct cell populations from adipose tissues and muscle that have the potential to form white or brown adipocytes in vitro and in vivo, following transplantation (Joe et al., 2010; Petrovic et al., 2010; Rodeheffer et al., 2008; Schulz et al., 2011; Uezumi et al., 2010”
What We Talk About When We Talk About Fat (2014, neutral): “These cells can be distinguished from myogenic satellite cells by the expression of PDGFRa, and they arise from a different developmental lineage than the surrounding muscle (Joe et al., 2010; Uezumi et al., 2010).”