Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy.

By Y. Lee, S. El Andaloussi, M. Wood. Human Molecular Genetics, 2012

879 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e14fdac3d6ac1df3afa67563c1601353211aa81

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Y. Lee
2. M. Wood
3. Ramesh C. Gupta
4. P. Vader
5. F. Aqil
6. Radha Munagala
7. E. Batrakova
8. J. Jeyabalan

In Molecular Biology

1. E. Batrakova
2. P. Vader
3. Imre Mäger
4. Ramesh C. Gupta
5. Y. Lee
6. C. Gregory
7. M. Wood
8. Janne Lehtiö

Citations in the corpus

• Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “Moreover, exosomes were harnessed for systemic delivery of exogenous siRNA across the biological barriers [20, 33, 37-39].”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “membrane-bound vesicles released from most, if not all, somatic cell types (reviewed in [140, 148, 149]).”
• Bovine milk-derived exosomes for drug delivery (2015, methodology): “Exosome protein lysates were prepared and verified with western blot analysis for vital exosomal membrane markers CD63, CD81, transpanins, Tsg101 and alix [23, 24] (Fig.”
• Matrix as an Interstitial Transport System (2014, background): “fuse directly with the plasma membrane, or taken up by a receptor-mediated process.(158) Nevertheless, the interaction between the miRNA and the target cell is highly specific and does not occur in random.”
• Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Accumulating evidence supports that the biogenesis, uptake and material cargo sorting of exosomes involve the endosomal sorting complex required for transport (ESCRT complex) and relevant proteins [14].”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “Morphological studies suggest that exosomes are derived from the microvesicle body (MVB) sorting pathway [34, 35].”
• Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties. (2015, neutral): “Hence, EVs are emerging as disease biomarkers and nanotherapeutics.(8) Despite progress in EV research, the challenge of purifying biologically intact EVs remains.”
• Origins, structures, and functions of circulating DNA in oncology (2016, background): “These microvesicles can possess a transforming capacity [117, 118] and constitute a key structure of cirDNA.”
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “For example, cryo-EM results indicate that the cupshaped appearance of ‘‘exosomes’’ as reported by TEM is an artifact of preparation (251).”
• Cells release subpopulations of exosomes with distinct molecular and biological properties (2016, methodology): “To explore the differences in RNA size distribution profiles of MV, LD-Exo and HD-Exo, we isolated total RNA from each source and analyzed it by Bioanalyzer® (Fig.”
• Influence of storage condition on exosome recovery (2016, neutral): “representative exosome markers in many studies [26,30,31].”