Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

By A. Zernecke, K. Bidzhekov, H. Noels, E. Shagdarsuren, L. Gan, B. Denecke, M. Hristov, T. Köppel, M. Jahantigh, E. Lutgens and 4 more. Science Signaling, 2009

1,364 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/20e23fc57550fe0b44aec5336b2600db1119128f

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In Cancer Research

1. Stefanie Dimmeler
2. E. Olson
3. A. Zeiher
4. E. Small
5. A. Llorente
6. María Yáñez-Mó
7. Ruben Garcia-Martin
8. R. Kahn

In Immunology

1. Christian Weber
2. Stefanie Dimmeler
3. W. Stoorvogel
4. H. Noels
5. A. Zeiher

In Molecular Biology

1. Stefanie Dimmeler
2. A. Zeiher
3. E. Olson
4. C. Urbich
5. E. Small
6. A. Llorente
7. María Yáñez-Mó
8. Zoraida Andreu

Citations in the corpus

• Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study (2015, background): “It is thought that the miRNAs bound to AGO are functionally inert [30], whereas those located inside exosomes remain functional and retain the potential to act upon mRNAs when their carrier exosomes are taken up by other cells [32].”
• Atherosclerosis: current pathogenesis and therapeutic options (2011, background): “miR-126 mediates degradation of RGS16, which unleashes autoregulatory CXCR4 signaling and increases endothelial production of CXCL12, a known mediator of progenitor cell mobilizatio”
• Pervasive roles of microRNAs in cardiovascular biology (2011, background): “miR-126 may also influence susceptibility to atherosclerosis, through the modification of endothelial cell functio”
• Matrix as an Interstitial Transport System (2014, background): “Several in vitro studies have demonstrated that exosomal miRNAs may participate in cell–cell communications in viral infection, immune response, atherosclerosis, and cancer progression.(153,161,162) More research is warranted to demonstrate validity of these mechanisms in physiological settings and ”
• The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation (2020, background): “miR-126 expression was shown to be a risk factor of T2D development, and this miRNA played a protective role in a mouse model of atherosclerosis [68,69].”
• Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, background): “Moreover, it has been described that specific miRNAs carried by apoptotic bodies are delivered to target cells and directly or indirectly regulate specific genes [62,63].”
• Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “, 2013), whereas miR-126 in apoptotic bodies produced by endothelial cells in the course of atherosclerosis reduces atherosclerotic plaque formation in mice (Zernecke et al., 2009).”
• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs (2012, background): “In particular, miR-126 was shown to provide an atheroprotective effec”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “During atherosclerosis, EC-derived apoptotic bodies enriched in miR-126 are generated and transfer paracrine ‘‘alarm signals’’ to recipient vascular cells, inducing CXCL12-dependent vascular protection (211).”