Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP31

By Hanfen Li, S. Willingham, J. Ting, F. Re. Journal of Immunology, 2008

704 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/9f0bc246d4e5d4a086792f6c9d6b92b69938bcef

How researchers see this paper

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In Immunology

1. J. Tschopp
2. G. Núñez
3. Fabio Martinon
4. E. Latz
5. Annick Mayor
6. L. Franchi
7. H. Hammad
8. H. Kono

In Molecular Biology

1. J. Tschopp
2. G. Núñez
3. E. Latz
4. Fabio Martinon
5. L. Franchi
6. Annick Mayor
7. H. Kono
8. K. Rock

In Surgery

1. J. Tschopp
2. H. Hammad
3. B. Lambrecht
4. G. Núñez
5. F. Liew
6. Kate Schroder

Citations in the corpus

• Mechanisms of Action of Adjuvants (2013, result): “Similar studies done by Li et al. (2008) showed that NLRP3 deficient mice injected with alum-adsorbed diphtheria toxoid or OVA vaccine elicited impaired levels of antigen-specific antibody responses.”
• IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation1 (2009, background): “IL-33 is released by endothelial or epithelial cell damage during trauma or infection (9, 43).”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “Although the NLRP3 inflammasome is involved in IgE induction by antigen and alum adjuvant (48, 50), its involvement in IgG1 induction is reported by some (47, 48) but not by others (49--51).”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “(202) showed a reduction in Alum-mediated IgG1 antibody-specific responses in Nlrp3 null mice.”
• Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, result): “Entirely in agreement with two recent studies by Eisenbarth and Li and colleagues (16, 26), our data show that alum adjuvant triggers activation of the NALP3 inflammasome.”
• The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA (2009, background): “It has been established that NLRP3 responds to both microbe-associated molecules and damageassociated molecular patterns (DAMPS) such as uric acid, alum salt, and silica (Dostert et al., 2008; Eisenbarth et al., 2008; Hornung et al., 2008; Li et al., 2008; Martinon et al., 2006).”
• The inflammasomes: guardians of the body. (2009, background): “Importantly, both MSU and alum depend on an intact inflammasome including NALP3, ASC, and caspase-1 to trigger a Th2-biased response (113, 117, 119).”
• The sterile inflammatory response (2010, background): “Subsequent studies by a number of groups found that NLRP3-deficient macrophages failed to produce mature IL-1β after stimulation with a variety of sterile particulate particles including silica (56, 57), alum (24, 56, 58, 59, 98), asbestos (57), and cholesterol crystals (Duewell et.”