Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

By M. Kool, Virginie Petrilli, T. de Smedt, Aline Rolaz, H. Hammad, M. van Nimwegen, I. Bergen, Rosa Castillo, B. Lambrecht, J. Tschopp. Journal of Immunology, 2008

643 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/ca36d867a140b7377965f791a0f4bb0bc976b693

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Tschopp
2. G. Núñez
3. Fabio Martinon
4. E. Latz
5. Annick Mayor
6. L. Franchi
7. H. Kono
8. K. Rock

In Molecular Biology

1. J. Tschopp
2. G. Núñez
3. E. Latz
4. Fabio Martinon
5. Annick Mayor
6. L. Franchi
7. H. Kono
8. K. Rock

Citations in the corpus

• The inflammasomes: guardians of the body. (2009, background): “Importantly, both MSU and alum depend on an intact inflammasome including NALP3, ASC, and caspase-1 to trigger a Th2-biased response (113, 117, 119).”
• NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, neutral): “…nucleotide-binding do eficient mice3; NLRs, receptors; NOMID, neon ; oxLDL, oxidized LDL; PAMPs, pathogen-asso rs; PYD, pyrin domain; RLRs, RIG-1-like helicas edoxin-1; TXNIP, thioredoxin-interacting P; T2 esponding author at: Institute of Biology Par 7, quai Saint Bernard, Bât A - 6ème étage -”
• The sterile inflammatory response (2010, background): “Subsequent studies by a number of groups found that NLRP3-deficient macrophages failed to produce mature IL-1β after stimulation with a variety of sterile particulate particles including silica (56, 57), alum (24, 56, 58, 59, 98), asbestos (57), and cholesterol crystals (Duewell et.”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “Although the NLRP3 inflammasome is involved in IgE induction by antigen and alum adjuvant (48, 50), its involvement in IgG1 induction is reported by some (47, 48) but not by others (49--51).”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, result): “By contrast, we and others (200, 203) did not observe a reduction in antigen-specific IgG antibodies titers following intraperitoneal immunization.”
• Mechanisms of Action of Adjuvants (2013, background): “Subsequent in vitro studies by various groups showed that activation of NLRP3 is required for alum-induced IL-1β and IL-18 secretion (Eisenbarth et al., 2008; Franchi and Nùñez, 2008; Hornung et al., 2008; Kool et al., 2008a).”