An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

By A. Mckie, D. Barrow, G. Latunde-Dada, A. Rolfs, Giamal Sager, Elida Mudaly, Melitta Mudaly, Christopher Richardson, David Barlow, A. Bomford and 6 more. Science, 2001

1,107 citations recorded by the source corpus.

Subfields: Hematology, Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/9dfe4a5c4881fc2fb5f75026f92ae5dad62b53c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. G. Papanikolaou
2. C. Wood
3. Kostas Pantopoulos
4. C. Brauner
5. A. Farrell
6. D. Richardson
7. D. Kalinowski

In Nutrition and Dietetics

1. G. Papanikolaou
2. C. Wood
3. Kostas Pantopoulos
4. C. Brauner
5. A. Farrell

Citations in the corpus

• Mechanisms for copper acquisition, distribution and regulation. (2008, neutral): “Alternatively, the duodenal metalloreductase dCytb (ref”
• Non-transferrin bound iron: a key role in iron overload and iron toxicity. (2012, neutral): “reductase which plays an important role at the level of the brush border membrane of the enterocytes [56], although it seems”
• The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer (2005, background): “This role is thought to be carried out by the membrane-bound duodenal cytochrome b enzyme, which has been found to possess ferric reductase activity (McKie et al., 2001).”
• Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells (2005, background): “An ascorbate-dependent b-type cytochrome ferrireductase, Dcytb (Cybrd1), expressed predominantly in the duodenum, was recently describe”
• Iron metabolism and toxicity. (2005, background): “The low pH of the gastric effluent dissolves ingested inorganic iron and facilitates its enzymatic reduction to the ferrous form by the brushborder ferrireductase Dcytb (McKie et al., 2001).”
• Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway (2002, background): “Fe3 in food is reduced to Fe2 by duodenal cytochrome b (McKie et al., 2001) and then absorbed into the enterocyte by an iron transporter protein DMT1 (Fleming et al., 1997; Gunshin et al., 1997).”
• Chemistry and biology of eukaryotic iron metabolism. (2001, background): “The recently identified iron-regulated ferrireductase with homology to cytochrome b561 is located in the brush border of the intestine and implicated to play a role in dietary iron absorption [38].”
• Identification of an intestinal heme transporter. (2005, methodology): “A rapid decrease in the xpression of DMT1 and Dcytb but not Ireg1 or hephaestin explains he mucosal block phenomenon of iron absorption.”
• Homeostasis and toxicology of essential metals (2012, background): “Before entry into the enterocytes, Fe (III) is reduced to Fe(II) either via an external reducing agent such as ascorbate or via an apical bound membrane ferric reductase, known as duodenal cytochrome b (Dcytb) (McKie et al., 2001; Latunde-Dada et al., 2002).”