Mechanisms for copper acquisition, distribution and regulation.

By Byung-Eun Kim, Tracy Nevitt, D. Thiele. Nature Chemical Biology, 2008

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Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases (2011, positive): “Thus, once transported by Cu uptake transporter hCTR1, soluble cytosolic Cu carrier proteins termed ‘‘Cu chaperones’’ are required for trafﬁcking Cu to speciﬁc Cu-containing enzymes through direct protein–protein interaction (116).”
Copper induces cell death by targeting lipoylated TCA cycle proteins (2022, background): “the animal kingdom, spanning bacteria to human cells (1).”
Cuproptosis: mechanisms and links with cancers (2023, background): “Conclusion and future perspectives Copper is essential for cell life, yet its excess has also been found to cause cell death [37].”
Survival strategies of arbuscular mycorrhizal fungi in Cu-polluted environments (2009, positive): “…18008 Granada, Spain e-mail: nuria.ferrol@eez.csic.es all organisms require copper as a catalytic cofactor for biological processes such as respiration, iron transport, oxidative stress protection, cellular metabolism, signal transduction, and normal cell growth and development (Kim et al. 2008).”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “Copper uptake occurs in a tightly regulated process through specific high-affinity plasma membrane copper transporters or low-affinity permeases [229,230].”