Identification of an intestinal heme transporter.

By M. Shayeghi, G. Latunde-Dada, J. Oakhill, A. Laftah, K. Takeuchi, N. Halliday, Y. Khan, A. Warley, F. McCann, R. Hider and 5 more. Cell, 2005

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Mechanisms of cell protection by heme oxygenase-1. (2010, background): “The heme carrier protein-1 (180, 181) is a cytoplasmic heme transporter (molecular weight: ∼125 kDa; human; Q86VB7) that can translocate into the plasma membrane in response to heme-Fe depletion, promoting the import of extracellular free heme (181, 182) (Figure 5).”
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. (2006, neutral): “During the course of the studies described below, this protein was reported by another group to be a heme carrier protein (HCP1) and entered into GenBank as such (Shayeghi et al., 2005).”
Homeostasis and toxicology of essential metals (2012, background): “Currently, there is debate over the presence of an intestinal heme transporter, with the candidate protein slc46a1 (heme carrier protein 1) (Shayeghi et al., 2005) being a potential folate transporter (Qiu et al., 2006; Laftah et al., 2009).”
Systemic iron homeostasis. (2013, background): “Despite the importance of heme and ferritin as dietary sources of iron, and despite some promising leads (196, 222, 241), little is known about their transport and metabolism in the enterocyte.”