Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

By R. Ohgami, D. Campagna, E. L. Greer, B. Antiochos, A. Mcdonald, Jing Chen, J. J. Sharp, Y. Fujiwara, J. Barker, M. Fleming. Nature Genetics, 2005

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Iron uptake mechanisms in plants: Functions of the FRO family of ferric reductases (2009, background): “As mentioned above, yeast FRE6 and mammalian STEAP1-4 localize to internal membranes and function as ferric chelate reductases [47–59].”
Non-transferrin bound iron: a key role in iron overload and iron toxicity. (2012, neutral): “Acta No NTBI NTBI present Tf-Fe TfR1 Endocytosis LIP Functional pool Storage pool Tf-Fe NTBI LIP Functional pool Storage pool ROS Lipids Proteins DNA DMT1 STEAP3 DMT1 /ZIP14 FERROPORTIN and other carriers of NTBI, especially those of lowmolecular weight is likely important.”
The Steap proteins are metalloreductases. (2006, methodology): “Recently, we identified an endosomal ferrireductase that facilitates transferrin cycle dependent iron uptake in erythroid precursors.(10,11) This protein, six transmembrane epithelial antigen of the prostate 3, Steap3, bears homology to oxidoreductases found in bacteria and archaea, as well as the F”