Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
By Z. Qian, Hongyan Li, Hongzhe Sun, K. Ho. Pharmacological Reviews, 2002
1,032 citations recorded by the source corpus.
Subfields: Hematology, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/b2d4e03063b6ef4efc54f6690ce12a9c6dcd42bd
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In Molecular Biology
Citations in the corpus
- Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, background): “The use of polysaccharides [70] such as heparin, chondroitin sulfate, and chitosan [70, 71] as carriers, and coupled with the use of antibody [72, 73] and transferrin [73, 74] as targeting motif has all brought significant clinical benefits.”
- Nanocarriers’ entry into the cell: relevance to drug delivery (2009, neutral): “healthy ones [138] (typically two- to ten-fold more).”
- Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer (2015, methodology): “This concept was tested by preparing non-viral vector Tf-PEG-PEInanoparticles with plasmids packed inside an outer PEG-PEI layer coated with Tf that binds with Tf-R with high affinity in the tumor cells (94, 389, 390) (depicted in the model in Figure 7).”
- Endocytic mechanisms for targeted drug delivery. (2007, background): “This advocates the use of TF as a targeting agent for drugs directed at brain disease [17].”
- Viruses and their uses in nanotechnology (2006, background): “Attachment of therapeutics to Tfn seemed a pragmatic approach for tumor-directed delivery [Qian et al., 2002; Singh, 1999].”
- Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. (2005, background): “e active targeting of anticancer agents, g cells via transferrin receptors [151,178,181,184]”
- Rational Approaches to Improving Selectivity in Drug Design (2012, background): “Thus, cancer cells can be specifically targeted by conjugating drugs to Tf. 161 The same phenomenon of local cellular pH is also an important regulator of protein structure and function in other systems.”
- Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “Transferrin has been investigated extensively as a potential lead for delivery of therapeutic agents that suffer from poor pharmacokinetic”
- Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “cer cells makes it an attractive overexpressed target in tumors [76].”