Programmed contraction of CD8+ T cells after infection

By V. Badovinac, Brandon B. Porter, J. Harty. Nature Immunology, 2002

712 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9da356ca7ce95cafc07e7f9f4f7fd76084b2f63f

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Citations in the corpus

The pathogenesis and diagnosis of foot-and-mouth disease. (2003, background): “Recently, it has been suggested that the immune system may “switch off” CD8 T-cells relatively early in infection, even if infection is not fully cleared (Badovinac et al., 2002; Harty and Badovinac, 2002).”
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation (2003, background): “Models of memory T cell differentiation The transition of effector CD4 + and CD8 + T cell responses to resting memory cells occurs after massive contraction of the response and is coincident with clearance of antige”
Pattern recognition receptors and control of adaptive immunity (2009, background): “Indeed, in the case of Listeria infection, the initial infectious dose and antigen dose are critical for determining the magnitude of the CD8 T-cell response, whereas the persistence of infection determines the duration of the response (16).”
Shaping and reshaping CD8+ T-cell memory (2008, background): “CD4 + T-cell help A brief interaction with antigen in vitro or in vivo 'programmes' CD8 + T cells with the capacity to differentiate into memory T cell”
Helping the CD8+ T-cell response (2004, background): “The picture that emerges from this set of results is that although short-term antigen stimulation might be sufficient to trigger a programme of CTL differentiation that includes multiple rounds of division, effector function and contractio”
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, background): “programmed ( Badovinac et al., 2002; Kaech and Ahmed, 2001).”
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes (2003, background): “Although transition through these stages was thought to be governed by the presence and eventual elimination of antigen, mounting evidence suggests that CD8 p T-cell development is guided by an instructional programme that, once set into motion during priming, is executed independentl”