FGF-21 as a novel metabolic regulator.

By A. Kharitonenkov, T. Shiyanova, A. Koester, Amy M. Ford, R. Micanovic, E. Galbreath, G. Sandusky, L. Hammond, J. Moyers, R. Owens and 8 more. Journal of Clinical Investigation, 2005

2,079 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9d1a79b3a57dca1fbf5489ebfeead55049e4f733

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In Molecular Biology

1. M. Mohammadi
2. Johan Auwerx
3. M. Kuro-o
4. A. Suomalainen
5. N. Itoh
6. B. Spiegelman
7. A. Hevener
8. R. Barnard

Citations in the corpus

• Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. (2013, background): “In white adipocytes, FGF21 stimulates glucose uptake in an insulin-independent manner (Kharitonenkov et al., 2005), modulates lipolysis (Chen et al., 2011b), enhances mitochondrial oxidative capacity (Chau et al., 2010), and potentiates PPARg activity (Dutchak et al., 2012).”
• Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “Muscle-derived factors including IL-6 (100, 101, 492, 493) IL-15 (514), BNDF (365, 424, 520), FGF21 (29, 64, 132, 164, 311, 349), and Follistatin-like 1 (482, 484), and SPARC (466) are a few putative myokines currently under investigation.”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “FGF21 regulation could as such contribute to the positive metabolic effects of SIRT1 activation (198).”
• Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State (2010, methodology): “Human recombinant FGF21 was expressed in Escherichia coli and refolded in vitro as previously described (5).”
• Fibroblast growth factor 21 corrects obesity in mice. (2008, background): “As expected based on previously reported results (2, 4, 5, 7), insulin levels were suppressed, and this effect reached its maximum at the lowest dose of FGF21.”
• Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. (2013, positive): “Since BAT and liver are major sources of FGF21 (21, 22), we measured FGF21 protein levels in these tissues.”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “FGF21 is an endocrine hormone that belongs to the FGF family and has been shown to play an important role in regulating the fasting response in the liver (Kharitonenkov et al. 2005; Badman et al. 2007; Inagaki et al. 2007).”
• FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. (2012, methodology): “Although FGF21 was originally found to stimulate insulin-independent glucose uptake in adipocytes through induction of GLUT1 expression (Kharitonenkov et al. 2005; Moyers et al. 2007) and to inhibit liploysis (Arner et al.”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “Expressed human gene in liver Resistant to diet-induced obesity (366)”