Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice.
By Zhuofeng Lin, H. Tian, K. Lam, Shao-qiang Lin, R. L. Hoo, M. Konishi, N. Itoh, Yu Wang, S. Bornstein, A. Xu and 1 more. Cell Metabolism, 2013
659 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3a35e64e65a44fa777f8d2581ed7b687d8855b7e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- B. Spiegelman
- E. Rosen
- D. Moller
- William L. Holland
- Manabu T. Nakamura
- J. Loor
- Liangyou Rui
- G. Hotamışlıgil
Citations in the corpus
- What We Talk About When We Talk About Fat (2014, positive): “In the absence of adiponectin, FGF21 can still reduce body weight but is no longer capable of improving glucose homeostasis, insulin resistance, hypertriglyceridemia, or hepatic steatosis (Holland et al., 2013; Lin et al., 2013).”
- Regulation of energy metabolism by long-chain fatty acids. (2014, background): “2, FGF21, a hormone important for adaptation to starvation, also induces adiponectin [109,110], suggesting that adiponectin plays a role in increasing metabolic activity of adipose during mobilization of fatty acids.”
- FGF/FGFR signaling in health and disease (2020, background): “FGF21 decreases insulin resistance, enhances fat oxidation, and suppresses hepatic steatosis in the liver of DIO and ob/ob mice,(553,554) which is related to the increased level of adiponectin in vivo.(556) FGF21 participates in high-fat, low-carbohydrate ketogenic diet-induced triglyceride clearanc”
- Malnutrition in Older Adults—Recent Advances and Remaining Challenges (2021, background): “Similarly, concentrations of adiponectin, a mediator of FGF21 functions increase with age [131] and are also associated with all-cause mortality in the old [132].”
- Energy Metabolism in the Liver (2014, positive): “FGF21 stimulates both lipolysis and the expression and secretion of adiponectin by adipose tissue (6, 72, 83, 150).”
- The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. (2013, background): “demonstrating reduced adiponectin levels in chow-fed FGF21 knockout mice (Holland et al., 2013; Lin et al., 2013).”