Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.

By B. Zheng, U. Albrecht, K. Kaasik, M. Sage, Weiqin Lu, S. Vaishnav, Qiu Li, Z. Sun, Gregor Eichele, A. Bradley and 1 more. Cell, 2001

914 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/9d0bcc516edf0d652bd7e560759b087b9b5554a1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. J. Takahashi
2. U. Albrecht
3. C. Dibner
4. U. Schibler

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. H. Ko
3. U. Albrecht
4. U. Schibler
5. Steve A. Kay
6. Ethan D. Buhr
7. David K. Welsh
8. C. Dibner

In Plant Science

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. Ethan D. Buhr
5. D. Weaver
6. U. Schibler
7. C. Dibner
8. Steve A. Kay

Citations in the corpus

• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Blunted FAA in Per2 mutant animals, containing a Per2 gene with a small in-frame deletion (111), may be due to an effect on FAA that is independent of the function of Per2 in the circadian clock.”
• System-level identification of transcriptional circuits underlying mammalian circadian clocks (2005, background): “( Clock and Arntl , also called Bmal1 or Mop3 ), two period gene”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Lack of Mc3r in mice leads to reduced FAA under restricted feeding conditions, and the expression of the clock genes Npas2 and Per2 in the cortex is also reduced (Sutton et al., 2008).”
• Circadian Rhythms in Isolated Brain Regions (2002, background): “The Per1 gene plays a role in the molecular mechanism underlying circadian rhythmicity in mammals (Bae et al., 2001; Zheng et al., 2001).”
• Coordination of circadian timing in mammals (2002, background): “mPER and mCRY outputs of the negative feedback loop are essential for maintaining a functioning circadian clock, as disruption of either the mPer1 and mPer2 genes together or both mCry genes causes immediate behavioural arrhythmicity when the double-knockout animals ”
• Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions (2006, neutral): “Three- to six-month-old C57BL/6 mice and Per1 −/− Per2 Brdm/Brdm mic”
• Molecular components of the mammalian circadian clock. (2006, background): “Per12/2 mice show slightly shorter (0.5– 1 h) free-running periods than the wild-type mice ( 14 ,40,44).”
• The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. (2002, neutral): “The three (Zheng et al., 2001).”
• Time zones: a comparative genetics of circadian clocks (2001, background): “All three PER proteins can weakly suppress CLOCK/BMAL1-dependent Per transcription in cultured mammalian cells, and genetic knockouts of two of the three paralogues ( Per1 and Per2 ) strongly affect behavioural rhythms in mic”