The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
By Loning Fu, H. Pelicano, Jinsong Liu, Peng Huang, Cheng Chi Lee. Cell, 2002
1,316 citations recorded by the source corpus.
Subfields: Aging, Endocrine and Autonomic Systems, Plant Science
View Paper: https://www.semanticscholar.org/paper/6148f5dacf640a37e3b02ddbf50c9eab0c5aff88
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
In Endocrine and Autonomic Systems
- J. Takahashi
- Paolo Sassone-Corsi
- U. Schibler
- D. Cardinali
- Phillip L. Lowrey
- U. Albrecht
- C. H. Ko
- J. Hirayama
In Plant Science
Citations in the corpus
- Melatonin--a pleiotropic, orchestrating regulator molecule. (2011, background): “…functions of clock genes, in particular, Per1 and Per2, are uncovered (Yang et al., 2009a,b) and in which circadian disruption, by mutation, inadequate signaling or frequently repeated phase shifts, reveals an increased cancer risk (Fu et al., 2002; Hardeland et al., 2003a; Lee et al., 2010).”
- Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. (2006, background): “Nevertheless, as described above, these different circadian mutants do display unique sets of pathological changes (Garcia et al. 2000; Fu et al. 2002; Miller et al. 2004; Gorbacheva et al. 2005; McClung et al. 2005; Spanagel et al. 2005; Turek et al. 2005).”
- The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “After a sublethal dose of IR, Per2 mutant mice and ATM heterozygous mice display a similar phenotype of coat graying, suggesting that Per proteins and the ATM kinase may function in a common pathway (Barlow et al., 1999; Fu et al., 2002; Lee, 2005).”
- A web of circadian pacemakers. (2002, background): “It is not yet clear whether the Hes-1 clock is active in cells of adult ani-and Mdm-2 (Fu et al., 2002).”
- Mammalian circadian biology: elucidating genome-wide levels of temporal organization. (2004, background): “Overexpression of c-myc subsequently causes DNA damage and tumor formation owing to loss of cell cycle control (62).”