Behavioral and neural analysis of extinction.

By Karyn M. Myers, Michael Davis. Neuron, 2002

899 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/9c1593057f9764ddb0b5eca68f009875a72e4c60

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. (2004, background): “The neural process of extinction of fear appears to use similar molecular and cellular mechanisms to those involved in fear conditioning.(17) Both fear learning and extinction are blocked by antagonists at the glutamatergic NMDA receptor,(18,19) a receptor known to be critically involved in learning”
Fear extinction in rats: implications for human brain imaging and anxiety disorders. (2006, methodology): “Pavlovian fear conditioning has been an influential animal model for the study of anxiety disorders (Buchel and Dolan, 2000; Myers and Davis, 2002; Sullivan et al., 2003; Charney, 2004).”
Neuronal signalling of fear memory (2004, background): “There is considerable interest in understanding the neurobiological mechanisms of fear extinction, and substantial progress has been made in recent year”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “NMDARs in the amgydala are also involved in the extinction of learned fear, which can be conceptualized as a different form of learning (Myers and Davis, 2002).”
Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. (2006, methodology): “US association , because extinction is context-specific (renewal), and an extinguished fear CR to the CS reappears with passage of time (spontaneous recovery) or after the US is presented alone without pairing with the CS (reinstatement) (see Myers and Davis, 2002 for review).”
Contributions of the amygdala to emotion processing: from animal models to human behavior. (2005, methodology): “One technique for altering learned emotional responses, especially those established as Pavlovian associations, is experimental extinction (Myers and Davis, 2002; Morgan et al., 1993; Bouton, 2002; Sotres-Bayon et al., 2004).”
Mediators and mechanisms of change in psychotherapy research. (2007, background): “Research has suggested that extinction is not merely unlearning (elimination of a previously established connection) because the connection is not erased or lost, but rather is actively suppressed through relearning of an acquired inhibition (Myers & Davis 2002).”
Stress and the brain: from adaptation to disease (2005, background): “This could be interpreted as a retention deficit that was entirely owing to altered GR function, but could also be regarded as behavioural extinction through the active consolidation of new and more appropriate informatio”
Extinction learning in humans: role of the amygdala and vmPFC. (2004, result): “In spite of these differencestioned fear (Myers and Davis, 2002), we found that amygin the paradigms across species, our findings in humansdala activation predicted the CR in both acquisition and are largely consistent with those from nonhuman an-early extinction.”
Towards a theory of chronic pain (2008, positive): “…important for normal behavior; impaired ability to extinguish is clinically relevant (e.g., in people suffering from phobias, panic disorder, and post-traumatic stress disorder), and its mechanisms have recently become a major focus of research (Myers and Davis, 2002; Sotres-Bayon et al., 2004).”
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures (2004, methodology): “This reminder is akin to an extinction trial in which the CS comes to predict no US and loses its ability to evoke a conditioned response (Pavlov, 1927; Baum, 1988; Bouton, 1993; Myers and Davis, 2002).”
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. (2006, background): “Furthermore, the activation pattern in his region during emotion regulation correlated with both the mygdala and lateral PFC, suggesting it might play a role in ediating the diminished amygdala response during conscious motion regulation.”
Memory processes in classical conditioning. (2004, result): “A growing literature on the brain processes involved in extinction is broadly consistent with the behavioral research just summarized (see [48] for one review).”
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic (2007, background): “A variety of behavioral observations support the hypothesis that extinction is a form of learning and not 'unlearning' or the forgetting of a conditioned association (reviewed in ref”
The Adolescent Brain and the Emergence and Peak of Psychopathology (2015, background): “Fear is a universal experience of impending threat or danger that is conserved across age, culture and mammalian species (LeDoux, 2000; Myers & Davis, 2002).”