Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures

By Akinobu Suzuki, Sheena A. Josselyn, Paul W. Frankland, S. Masushige, Alcino J. Silva, S. Kida. Journal of Neuroscience, 2004

1,153 citations recorded by the source corpus.

Memory retrieval is not a passive phenomenon. Instead, it triggers a number of processes that either reinforce or alter stored information. Retrieval is thought to activate a second memory consolidation cascade (reconsolidation) that requires protein synthesis. Here, we show that the temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories. We also report that reconsolidation and extinction, two opposing processes triggered by memory retrieval, have distinct biochemical signatures: pharmacological antagonism of either cannabinoid receptor 1 or L-type voltage-gated calcium channels blocks extinction but not reconsolidation. These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6fb4fbedd5e397bca41ba0ee325a00d98a15854a

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Citations in the corpus

The restless engram: consolidations never end. (2012, background): “This appears to depend on the task and on the kinetics of RC presentation (Eisenberg et al. 2003, Suzuki et al. 2004, Garelick & Storm 2005, Monfils et al. 2009, Perez-Cuesta & Maldonado 2009, de la Fuente et al. 2011).”
Sleep, memory, and plasticity. (2006, background): “Following reactivation and blockade of reconsolidation, previously learned behaviors are still intact 2 hours (Suzuki et al. 2004) and 4 hours (Debiec et al. 2002, Duvarci & Nader 2004, Nader et al. 2000) later, with no sign that degradation has begun.”
The molecular and systems biology of memory. (2014, neutral): “, 2003), the duration of the reactivation trial (Pedreira and Maldonado, 2003; Suzuki et al., 2004), and the presence of new information in the retrieval trial (Pedreira et al.”
Cannabidiol as a Potential Treatment for Anxiety Disorders (2015, background): “which the memory trace may either be reconsolidated or extinguished [97], and this process may be pharmacolog-”
A single standard for memory: the case for reconsolidation (2009, background): “A similar effect was recently reported using contextual fear conditioning [120].”
Sleep-dependent memory consolidation and reconsolidation. (2007, background): “Following reactivation and blockade of reconsolidation, previously learned behaviors are still intact 2–4 h later [26,27,31,32].”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “…4-yl)-propyl-1-phosphonic acid) before extinction training did not prevent acquisition of extinction, but did impair retrieval of extinction the following day (Santini et al, 2001; Suzuki et al, 2004), suggesting a role for NMDArs in consolidation, rather than in acquisition, of extinction.”
Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? (2005, background): “commun.) and mouse contextual fear conditioning [ 37 ].”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, neutral): “There is some evidence for impaired extinction, involving both within-session extinction and extinction recall, upon systemic application of the Ca(2) channel blockers nifedipine and nimodipine (19, 57, 58, 492).”