Extinction learning in humans: role of the amygdala and vmPFC.

By Elizabeth A. Phelps, Mauricio R. Delgado, Katherine I. Nearing, Joseph E LeDoux. Neuron, 2004

1,783 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/434e121afd0e189853775ea31cbab0396417739c

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Citations in the corpus

Phasic and sustained fear in humans elicits distinct patterns of brain activity (2010, neutral): “Consistent with animal research centrally implicating the amygdala in cued fear conditioning and extinction, neuroimaging studies in humans have likewise implicated the amygdala in fear acquisition and extinction (Buchel et al., 1998; LaBar et al., 1998; Milad et al., 2007; Phelps et al., 2004).”
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. (2006, methodology): “Employing a novel extinction retention design (Milad et al 005a) with similarities to that of Phelps et al (2004), Milad et al 2005b) conducted a morphometric MRI study in 14 healthy umans to test for correlations between regional cortical thickess and extinction recall.”
Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity (2009, background): “Amygdala activity is a prominent correlate of anticipatory anxiety (Nitschke et al., 2009), conditioned fear in anticipation of shock (Phelps et al., 2004), and reported negative emotion in response to affective pictures (Ochsner & Gross, 2008; Ochsner et al., 2004; Phan et al., 2005).”
The ecology of human fear: survival optimization and the nervous system (2015, background): “…situations, interoception, motivation, metabolic needs, and the functioning Frontiers in Neuroscience | www.frontiersin.org 12 March 2015 | Volume 9 | Article 55 of domain-general cognitive machinery which is integrated at both the emotional regulation and strategy; and (ii) Learning…”
Fear extinction in rats: implications for human brain imaging and anxiety disorders. (2006, background): “Phelps et al. (2004) showed that vmPFC deactivation was negatively correlated with the extinction recall.”
Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. (2006, background): “A recent human brain imaging study also reported reduced activation of the mPFC during fear conditioning, which diminished as extinction progressed (Phelps et al., 2004).”
The cognitive control of emotion. (2005, background): “Although the precise systems recruited and the nature of interactions among them have differed across studies and paradigms, instrumental avoidance of aversive stimuli [42], extinction of classically conditioned fear responses [58, 59 ] and reversal of stimulus‐reward associations [60‐63] have been ”
Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. (2007, background): “In an fMRI experiment by Phelps et al. (2004), vmPFC activation during extinction recall in healthy humans significantly correlated with extinction training on the previous day.”
Emotion and cognition: insights from studies of the human amygdala. (2006, result): “The pattern of this activation and its location within the medial PFC mirrored those observed when fear was diminished with extinction learning (Phelps et al. 2004).”
Neural pathways link social support to attenuated neuroendocrine stress responses (2007, background): “Several of these studies seem to implicate the pACC as involved in regulatory processes (Das et al., 2005; Most et al., 2006), although some implicate regions of the dACC (Ochsner et al., 2002) and subACC (Kim et al., 2003; Phelps et al., 2004) as well.”
The neural architecture of emotion regulation (2007, background): “…instrumental avoidance of aversive stimuli (Jensen et al., 2003), extinction of classically conditioned fear responses (Gottfried & Dolan, 2004; Phelps, Delgado, Nearing, & LeDoux, 2004), and reversal of stimulus–reward associations (Cools, Clark, Owen, & Robbins, 2002; Kringelbach & Rolls,…”
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder (2009, background): “In a study with functional magnetic resonance imaging (fMRI) (48), amygdala was activated during extinction learning, whereas vmPFC was activated during extinction recall.”
Amygdala and Ventromedial Prefrontal Cortex Are Inversely Coupled during Regulation of Negative Affect and Predict the Diurnal Pattern of Cortisol Secretion among Older Adults (2006, neutral): “One plausible route is via medial PFC (MPFC), which has direct connections with lateral/dorsal PFC and also with the amygdala (Price, 2005), and has been implicated in extinction of conditioned fear (Quirk et al., 2003; Phelps et al., 2004).”