Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.

By K. Ressler, B. Rothbaum, Libby R. Tannenbaum, Page L. Anderson, K. Graap, E. Zimand, L. Hodges, Michael Davis. Archives of General Psychiatry, 2004

1,013 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/72a23c0e833384a7986084dd0ac092c11fb727bb

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Citations in the corpus

Contributions of the amygdala to emotion processing: from animal models to human behavior. (2005, background): “It has recently been reported that the administration of d-cycloserine to humans prior to exposure therapy for the treatment of phobia enhances the treatment response (Ressler et al., 2004).”
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis (2006, background): “Furthermore, functional brain imaging studies now provide evidence that D-cycloserine enhances left superior temporal gyrus activation in schizophrenic subjects performing a memory task and that the response correlates significantly with the reduction in negative symptoms (YurgelunTodd et al., 2005)”
Understanding how and why psychotherapy leads to change (2009, background): “Activation of the critical receptor (with Dcycloserine vs. a placebo) has improved the therapeutic effects for individuals with acrophobia (fear of heights) as reflected on paper-and-pencil, physiological, and behavioral measures (Ressler et al., 2004).”
Mediators and mechanisms of change in psychotherapy research. (2007, background): “An initial controlled trial was completed with individuals who suffered acrophobia (fear of heights) (Ressler et al. 2004).”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “…receptor agonist Pamplona et al, 2006 dexamethasone glucocorticoid receptor agonist Yang et al, 2006 PEPA AMPA receptor potentiator Zushida et al, 2007 Clinical DCS partial NMDAr agonist Ressler et al, 2004; Hofmann et al, 2006 cortisol endogenous glucocorticoid Soravia et al, 2006 Box 1 Extinction”
Role of Inhibition in Exposure Therapy (2012, background): “Nevertheless, in excellent clinical translation work, dcycloserine has been shown to result in less fear at follow-up, after exposure therapy for specific human fears (Ressler et al. 2004).”