Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

By A. Nimmerjahn, F. Kirchhoff, Fritjof Helmchen. Science, 2005

5,654 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/99f1cc3b9f1d05faa60bdfa6a414ad270e0c6c9c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Neurology

Citations in the corpus

The biphasic function of microglia in ischemic stroke (2017, positive): “The processes of microglia are constantly in motion and survey the local microenvironment of the brain (Nimmerjahn et al., 2005).”
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “They continuously survey the brain parenchyma to detect any alterations in their microenvironment.(302,304,305) Since it can reduce inflammation, it is beneficial for dead and dying neurons to undergo phagocytosis.”
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia (2008, background): “Microglia are primarily involved in immune surveillance [16,17], but when activated have macrophage-like capabilities including phagocytosis, inflammatory cytokine production, and antigen presentation [18].”
Microglia: biology and pathology (2009, background): “The spectrum of suitable positron emission tomography ligands has been extended in the meantime [114, 185, 186], and it has also become possible to watch microglial cells patrolling and at work in the living brain using two-photon microscopy [137].”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “Recent in vivo time-lapse imaging has revealed dynamic interactions between microglia and neurons in the brain following lesion or injury (Davalos et al., 2005; Nimmerjahn et al., 2005).”
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. (2012, methodology): “In vivo activity of microglia has recently been visualized using two photon microscopy techniques (Davalos et al. 2005; Nimmerjahn et al. 2005; Wake et al. 2009).”
Visceral influences on brain and behavior. (2013, neutral): “Lamina 1 also carries information experienced as positive feelings, e.g., ‘‘sensual touch,’’ originating from unmy- elinated fibers within cutaneous or mucosal epithelia evoked by slow, light, repeated mechanical stimuli (Nordin, 1990).”
Control of microglial neurotoxicity by the fractalkine receptor (2006, background): “Microglia, which have characteristics of immature myeloid cells, sample the extracellular space of the healthy CNS through continuous extension, retraction and remodeling of cellular processe”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Despite the downregulated phenotype of microglia in the normal healthy brain, in vivo imaging studies demonstrate that the fine processes of microglia continually palpate and monitor their local microenvironment (5, 6).”
Glia and pain: Is chronic pain a gliopathy? (2013, background): “Interestingly, even acute opioid treatment after a subcutaneous injection results in marked SGC reaction in DRGs at 2 hours when morphine analgesia declines [18] (Table 1).”
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. (2012, neutral): “constantly survey their microenvironment for noxious agents and injurious processes (Nimmerjahn et al., 2005).”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “ing’’ microglial processes were found to be highly motile (Nimmerjahn et al., 2005), and to continuously and dynamically”
Microglial cell origin and phenotypes in health and disease (2011, background): “Steady-state microglia and homeostasis in the CNS In the steady state, microglia exhibit a resting phenotype characterized morphologically by extensively ramified processes that perform continuous surveillance of their surroundings in the CN”
Systemic infections and inflammation affect chronic neurodegeneration (2007, background): “Although the microglia are phenotypically downregulated, recent imaging studies in vivo show that these cells, even in their so-called resting state, are highly active, with their fine processes continually surveying their local microenvironmen”