Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum.

By Arvind Kumar, Kwang H. Choi, W. Renthal, Nadia M. Tsankova, D. Theobald, Hoang-Trang Truong, S. Russo, Q. LaPlant, Teresa S. Sasaki, Kimberly N. Whistler and 3 more. Neuron, 2005

777 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/99e9f7f49fd2d760a1680f8d3ce10171d3d05f74

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. E. Nestler
2. R. Malenka
3. S. Hyman
4. S. Russo
5. V. Krishnan
6. L. Monteggia
7. W. Renthal
8. Arvind Kumar

In Neurology

1. Courtney A. Miller
2. E. Nestler
3. J. Sweatt
4. Guanghua Xiao
5. V. Krishnan
6. R. Malenka
7. L. Monteggia
8. Gina G. Turrigiano

Citations in the corpus

• Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “The importance of associative memory does not exclude a role for long-lived homeostatic adaptations in addiction and its persistence; for example, cocaine has been shown to induce chromatin remodeling (Kumar et al. 2005), a www.annualreviews.org • Neural Mechanisms of Addiction 569 A nn u.”
• Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol (2008, result): “…of c-fos and zif268 after repeated cocaine administration observed here, in agreement with previous reports in which the drugs were injected in the home cage or in environments to which animals were previously habituated (Hope et al., 1992, 1994; Wang and McGinty, 1995; Kumar et al., 2005).”
• BDNF — a key transducer of antidepressant effects (2015, background): “Activity-dependent BDNF transcription can also be regulated by epigenetic changes of the chromatin structure, adding yet another level of regulation (Kumar et al., 2005; Zhou et al., 2006).”
• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “…can control gene transcription in the nervous system and modulates long-term memory formation (Guan et al., 2002; Alarcón et al., 2004; Korzus et al., 2004; Levenson et al., 2004, 2006; Kumar et al., 2005; Chwang et al., 2006; Bredy et al., 2007; Fischer et al., 2007; Lubin and Sweatt, 2007).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “Moreover, butyrate also facilitates neuronal plasticity induced by drugs of abuse, such as cocaine or amphetamine (e.g. Febo et al., 2009; Kalda et al., 2007; Kumar et al., 2005; Sanchis-Segura et al., 2009; Schroeder et al., 2008; Shen et al., 2008) (Table 2 ).”
• Mouse and rat BDNF gene structure and expression revisited (2006, background): “…that histone modifications at specific BDNF promoters are involved in chromatin remodeling during electroconvulsive seizures (Tsankova et al., 2004) and cocaine-induced plasticity (Kumar et al., 2005) in rat and in a mouse model of depression and antidepressant treatment (Tsankova et al., 2006).”
• Covalent modification of DNA regulates memory formation. (2007, positive): “Recent evidence indicates that regulation of chromatin structure serves as an important control mechanism in memory-associated transcriptional regulation (Swank and Sweatt, 2001; Guan et al., 2002; Huang et al., 2002; Levenson et al., 2004a, 2006; Korzus et al., 2004; Alarcon et al., 2004; Wood et a”
• The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “One such target is cyclin dependent kinase 5 (Cdk5), which is induced by cocaine in NAc via ΔFosB [80] and known in other systems to regulate RhoGTPases.”
• Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. (2007, positive): “The overexpression of a related class II HDAC, HDAC9, in the NAc had no effect (Figure 2C), although overexpression of HDAC4 exerted a similar effect (Kumar et al., 2005).”
• Epigenetic regulation in psychiatric disorders (2007, background): “For example, cocaine and antipsychotic drugs induce acetylation of histone H4 and phosphoacetylation of histone H3 in the striatum (a brain region that is important for the behavioural effects of these drugs; see below”
• Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “First, global (that is, total cellular) levels of H3 and H4 acetylation are increased in the NAc after acute or chronic exposure to cocain”