Covalent modification of DNA regulates memory formation.

By Courtney A. Miller, J. Sweatt. Neuron, 2007

1,183 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a2280cfed64bbce829cd14affa283c558f7f73b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. C. Alberini
2. Michael Joseph Meaney
3. Jian‐Kang Zhu
4. M. Lamb
5. Eva Jablonka
6. G. Fan
7. Thuc M. Le
8. F. Lubin

In Genetics

1. C. Alberini
2. E. Nestler
3. Michael Joseph Meaney
4. Jian‐Kang Zhu
5. Thuc M. Le
6. G. Fan
7. Eva Jablonka
8. M. Lamb

In Molecular Biology

1. C. Alberini
2. Michael Joseph Meaney
3. E. Nestler
4. Jian‐Kang Zhu
5. Thuc M. Le
6. G. Fan
7. Eva Jablonka
8. M. Lamb

Citations in the corpus

• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, positive): “Furthermore, identifying a role for DNMTs in the methylation of the bdnf gene in the adult hippocampus expands the current understanding of the regulation of epigenetic marks after cellular differentiation in this brain region (Levenson et al., 2006; Miller and Sweatt, 2007).”
• Dynamic DNA methylation programs persistent adverse effects of early-life stress (2009, positive): “Focusing on DNA methylation, our results provide evidence for postmitotic epigenetic modifications in neuronal function; such modifications can serve to facilitate (or disfavor) physiological and behavioral adaptation”
• Dnmt1 and Dnmt3a are required for the maintenance of DNA methylation and synaptic function in adult forebrain neurons (2010, neutral): “Recently, studies with Dnmt inhibitors in in vitro brain slices or hippocampus in vivo”
• Epigenetics and the biological definition of gene x environment interactions. (2010, positive): “More recent studies suggest that comparable epigenetic modifications associate with learning and memory (Lubin et al., 2008; Miller & Sweatt, 2007), chronic exposure to drugs of abuse (Renthal & Nestler, 2008), and psychiatric illness (Grayson et al., 2005; Ptak & Petronis, 2008; Tsankova et al.,…”
• A taxonomy of biological information (2010, background): “Non-genetic information can be transferred by a diversity of vehicles, ranging from molecules to behavior (Jablonka et al. 1998, Danchin et al. 2004, Wood and Oakey 2006, Jaffee and Price 2007, Miller and Sweatt 2007, Wilkinson et al. 2007, Champagne 2008, Hager et al. 2008, Mesoudi 2008).”
• Active DNA Demethylation Mediated by DNA Glycosylases (2009, positive): “DNA methylation is required for the inactivation of the memory suppressor gene PP1, whereas active DNA demethylation is associated with the activation of the memorypromoting gene reelin (69).”
• DNA Demethylation Dynamics (2011, background): “…for decades, recent advances discussed here now support the hypothesis that DNA demethylation and methylation may be bidirectional and dynamically regulated throughout early and late development and in certain adult tissues, especially the brain (Guo et al., 2011; Miller and Sweatt, 2007).”
• Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, positive): “These results lead to the conclusion that DNA methylation is dynamically regulated in the adult nervous system and that this cellular mechanism is a crucial step in memory formation (169).”
• The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers (2010, positive): “Recent studies using rodent models provided strong support for an idea that the nervous system has co-opted epigenetic mechanisms utilized during development for activity-dependent brain functions, including the generation and maintenance of long-term behavioral memories in adulthood [30,31].”
• Epigenetic regulation in psychiatric disorders (2007, background): “Contextual fear conditioning induced DNA methyltransferase 3A( Dnmt3A ) and Dnmt3B expression in CA1 of the hippocampus, and administration of the DNMT inhibitors zebularine and 5-aza-2′-deoxycytidine blocked the induction of both contextual fear conditionin”
• Soft inheritance: challenging the modern synthesis (2008, positive): “…it seems that early maternal behavior in rats has long-term effects that are associated with chromatin marks (see later) in a key gene in their offspring’s brain cells (Weaver et al., 2004); changes in marks are also known to be associated with fear conditioning in rats (Miller and Sweatt, 2007).”
• How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “DNA methylation is also up-regulated in the hippocampus and amygdala after fear conditioning, and inhibition of DNA methylation blocks fear LTM (Miller and Sweatt 2007; Monsey et al. 2011).”