Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

By K. Petersen, S. Dufour, D. Befroy, R. Garcia, Gerald I. Shulman. New England Journal of Medicine, 2004

2,223 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/9816067e1308da31e5584238782e06a507061643

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In Endocrinology, Diabetes and Metabolism

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Citations in the corpus

The anti-inflammatory effect of exercise. (2005, background): “In humans, circulating IL-6 levels may (6, 107) or may not (18, 106) be associated with insulin resistance.”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Plasma IL-6 concentrations predict the development of T2DM (Vozarova et al. 2001), and peripheral administration of IL-6 induces hyperlipidemia, hyperglycemia, and insulin resistance in rodents and humans (Stith and Luo 1994; Tsigos et al. 1997; Petersen et al. 2005).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “…favor the hypothesis that inherited or induced transcriptional downregulation of mitochondrial transcripts (Mootha et al., 2003; Patti et al., 2003, Petersen et al., 2004) is a protective mechanism which counteracts insulin resistance, rather than a pathogenic mechanism contributing to insulin…”
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007, background): “In fact, there is a strong correlation between the presence of intramyocellular lipid in skeletal muscle and liver and progression of type II diabetes (Guan et al, 2002; Kelley et al, 2002; Petersen et al, 2004).”
AMPK: an emerging drug target for diabetes and the metabolic syndrome. (2009, background): “More recently, defects in fatty acid oxidation have been considered the primary causal factors in the development of muscle insulin resistance (Petersen et al., 2004).”
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. (2008, methodology): “In addition, (31)P magnetic resonance spectroscopy may be used in conjunction with the glucose clamp to assess rates of insulin-stimulated muscle mitochondrial ATP synthase flux and insulin-stimulated increases in concentrations of intramyocellular inorganic phosphate (75).”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “ficiency has been found in the insulin-resistant offspring of patients with type 2 diabetes (164).”
Regulation of mitochondrial biogenesis (2010, background): “In further studies, Petersen and co-workers [47,49] measured basal rates of mitochondrial function in human skeletal muscle of young, lean and sedentary insulin-resistant offspring of parents with Type 2 diabetes.”
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “In individuals with type 2 diabetes, whole muscle fatty acid oxidation also appears to be reduced (18), and basal mitochondrial oxidative phosphorylation was reduced in insulin-resistant offspring of patients with type 2 diabetes (331).”