Evidence that fragile X mental retardation protein is a negative regulator of translation.

By B. Laggerbauer, D. Ostareck, Eva‐Maria Keidel, A. Ostareck-Lederer, Utz Fischer. Human Molecular Genetics, 2001

594 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9749258cdae0643d2d882dcd8065a5736b79ccb6

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Citations in the corpus

Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles (2005, background): “Indeed, FMRP suppresses translation both in vitro and in vivo”
Dendritic mRNA: transport, translation and function (2007, background): “The binding of FMRP to mRNA is thought to inhibit translatio”
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. (2001, background): “Although FMRP has been shown to sup-9–11, used for microarray analysis, are underlined. press translation of bound messages in vitro (Li et al.,(B) Venn diagram of the number of genes altered in polyribosomal 2001; Laggerbauer et al., 2001), perhaps accounting forfractions and total lysate.”
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway (2004, background): “It has been shown that FMRP could suppress protein translation in vitro”
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. (2002, background): “Indeed, biochemical studies suggest that FMRP acts as a negative regulator of translation (Laggerbauer et al. 2000; Li et al. 2000; Schaeffer et al. 2001).”
The mGluR theory of fragile X mental retardation. (2004, unknown): “Experiments in vitro initially suggested the possibility that FMRP is a general repressor of translation [ 50 ,51].”
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, unknown): “Regulation of Local Translation: Excess and Dysregulated in Fragile X FMRP can repress mRNA translation in vitro (Laggerbauer et al., 2001; Li et al., 2001), and a general consequence of FMRP deficiency in vivo is excess synthesis of specific proteins (Lu et al., 2004; Muddashetty et al., 2007;…”