Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.

By V. Brown, Peng Jin, S. Ceman, J. Darnell, W. T. O'donnell, S. Tenenbaum, Xiaokui Jin, Yue Feng, K. Wilkinson, Jack D. Keene and 2 more. Cell, 2001

1,104 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/41ed96d3f1db9e92770068e1be530a646d5f4294

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Citations in the corpus

Fragile X Mental Retardation Protein: A Paradigm for Translational Control by RNA-Binding Proteins (2015, background): “Some of the identified target mRNAs have putative GQ sequences and code for proteins that are critical for synaptic modifications (Brown et al., 2001), which is consistent with the idea that the loss of translational regulation of these mRNAs by FMRP will lead to changes in the structure and functio”
G-quadruplexes and their regulatory roles in biology (2015, background): “FMRP binds specifically to its own mRNA through a G-quadruplex present in its 5′ UTR, which impedes translation giving rise to altered brain mRNA translational profiles (103).”
Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “In these animals, the translation of mRNAs to which FMRP binds is thought to be derepressed because protein levels encoded by the FMRP-binding mRNAs are increased (Brown et al., 2001; Garber et al., 2006).”
Correction of fragile X syndrome in mice. (2007, background): “…was proposed (Bear et al., 2004), based on the following four observations: (1) FMRP can function as a repressor of mRNA translation at synapses (Brown et al., 2001; Qin et al., 2005); (2) synaptic protein synthesis is stimulated Neu potently by activation of group 1 (Gp1) mGluRs,…”
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, positive): “In contrast to NR2A and NR2B, the NR1 mRNA was not associated with FMRP by the coimmunoprecipitation assay (Figure 8A), nor was there coprecipitation of GAPDH mRNAs, a commonly used negative control that is believed not to be regulated by FMRP (Brown et al., 2001).”
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, positive): “In addition, dendritic mRNA localization was observed for SAPAP3 (Kindler et al., 2004), already appreciated to be an FMRP ligand (Brown et al., 2001).”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, methodology): “These procedures were carried out as described [43].”
Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles (2005, background): “Much effort has been put into identifying the mRNA targets of FMR”
Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast (2004, background): “…(Costanzo et al. 2001; Issel-Tarver et al. 2002), for only a few of these proteins have the RNA targets been systematically identified (Takizawa et al. 2000; Tenenbaum et al. 2000; Brown et al. 2001; Hieronymus and Silver 2003; Li et al. 2003; Shepard et al. 2003; Waggoner and Liebhaber 2003).”
Pushing the limits of the scanning mechanism for initiation of translation (2002, neutral): “Human genetic disorders have been traced also to disruption of regulatory mechanisms mediated by mRNA binding proteins (Brown et al., 2001; Cazzola and Skoda, 2000; Cazzola et al., 2002; Kaytor and Orr, 2001; Mikulits et al., 1999).”
5′-UTR RNA G-quadruplexes: translation regulation and targeting (2012, background): “Immunoprecipation followed by genome-wide microarray analysis studies of the RNA-binding FMPR protein and the RHAU helicase have provided some evidence for RNA G-quadruplex in cellular mRNAs (38,58).”
Human MicroRNA Targets (2004, methodology): “…density protein miR-125a d , miR-135, miR-324–3p FACL3 b,c Brown et al. 2001 123983 Long-chain Acyl-CoA synthetase 3 let-7 d , miR-141, miR-98 FMR1 c Brown et al. 2001 102081 FMRP1 miR-194 d , miR-297 d , miR-326 FMR2 Chen et al. 2003 155966 FMRP2 miR-152 d FXR1 b Denman 2003 114416 FMRP1 let-7 d…”
Dendritic mRNA: transport, translation and function (2007, background): “Surprisingly, however, mice that lack FMRP exhibit both up- and downregulation of putative FMRP target”