Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.

By Yumei Xiong, N. Miyamoto, K. Shibata, M. Valasek, T. Motoike, R. Kedzierski, M. Yanagisawa. Proceedings of the National Academy of Sciences of the United States of America, 2004

697 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/97349589b0d6121c57655cb3c388c5282880baff

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In Endocrine and Autonomic Systems

1. M. Oba
2. B. Bradford
3. M. Allen

In Nutrition and Dietetics

1. R. Gambino
2. G. Musso
3. Jeffrey I. Gordon
4. M. Cassader

In Physiology

1. Rosa Krajmalnik-Brown
2. R. Gambino
3. M. Cassader
4. G. Musso
5. J. DiBaise
6. F. Rey
7. Dae-Wook Kang
8. Z. Ilhan

Citations in the corpus

• Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008, background): “SCFAs (C1-C6), which are ligands for Gpr41, stimulate expression of leptin, a polypeptide hormone with pleiotropic effects on appetite and energy metabolism, in mouse-cultured adipocytes (11).”
• Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) (2011, background): “Gpr41 had been reported to be expressed in adipose tissue in mice (19) and humans (14) and to stimulate leptin secretion (18, 19).”
• Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. (2005, background): “in both a mouse adipocyte cell line and mouse adipose tissue in primary culture, and acute oral administration increased circulating leptin levels in mice (10).”
• The role of short-chain fatty acids in immunity, inflammation and metabolism (2020, background): “The proven SCFAs receptors mainly include G protein-coupled receptors GPR109A (also called hydroxycarboxylic acid receptor 2, HCAR2), GPR43 (also called free fatty acid receptor 2, FFAR2) and GPR41 (also called Free fatty acid receptor 3, FFAR3) (Le Poul et al. 2003; Tolhurst et al. 2012; Wang et al”
• Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation (2014, background): “GPR41 is also expressed in adipocytes, renal smooth muscle cells, enteric neuronal cells, and pancreatic cells (Table I) (42,43).”