Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.

By Yeon-Hee Hong, Y. Nishimura, D. Hishikawa, H. Tsuzuki, H. Miyahara, Chizu Gotoh, Ki-Choon Choi, D. Feng, Chen Chen, Hong-Gu Lee and 3 more. Endocrinology, 2005

632 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f8b4685536211debf0e21db954a6357843cf90ab

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Citations in the corpus

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 (2012, background): “In fact, they are better characterized as mediators of SCFA effects on immune cells and adipocytes (17,18,20), where they have been implicated in modulating neutrophil activation (18,20), reducing inflammation by inhibition of cytokine and chemokine expression, enhancing leptin production (29), stim”
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism (2020, background): “FFAR2 expression has been identified along the entire gastrointestinal tract and white adipocytes [38,39].”
Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms (2012, background): “However, the role of FFAR3 in mediating these effects remains controversial [23,24].”
The Effect of Stocking Density on Stress Related Genes and Telomeric Length in Broiler Chickens (2010, methodology): “Semi-quantitative RT-PCR analysis was performed as previously described (Hong et al., 2005) to measure the levels of HSP70, HSP90, HMGCR and beta-actin mRNAs.”
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) (2011, result): “The results further confirmed the previous reports that SCFAs can promote leptin secretion from adipose and not via GPR41 (29, 30).”
The role of short-chain fatty acids in immunity, inflammation and metabolism (2020, background): “The increase of short-chain fatty acids in the circulation is closely related to the decrease of lipogenesis and lipolysis of fat cells (Hong et al. 2005).”
Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation (2014, background): “Secretion of PYY and GLP-1, adipocyte development, adipogenesis, suppression of lipolysis, epithelial innate immunity, antitumor activity, anti-inflammatory effect, and Treg differentiation (39, 40, 43, 46, 47, 58, 116-121)”
The human gut microbiota: Metabolism and perspective in obesity (2018, background): “SCFA increased the expression of PPARs, an important mediator of adipogenesis.(43) SCFAs that are bound to GPCR41 stimulate the expression of leptin in adipocytes and those that bind to GPCR43 appear to stimulate adipogenesis.”
Short chain fatty acids in human gut and metabolic health. (2020, neutral): “Hong et al. (2005) demonstrated that treatment of 3T3-L1 preadipocytes with acetate and propionate for seven days increased adipogenesis.”
Free Fatty Acid Receptors in Health and Disease. (2020, background): “However, other groups were unable to detect FFAR3 expression in mouse adipose tissue by qRT-PCR or in situ hybridization analysis (98, 119, 157).”
Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation (2015, background): “Similarly, whether and how the PPARg-dependent pathway interacts with GPR41 and/or GPR43 signaling remains to be established.”