Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

By Ilan Gabriely, Xiao Hui Ma, Xiao Man Yang, G. Atzmon, Michael W. Rajala, A. Berg, P. Scherer, L. Rossetti, Nir Barzilai. Diabetes, 2002

609 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/9680842bb7dc99f691d9f0ff00b409c059b65dc4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Gerald I. Shulman
2. J. Speakman
3. A. Chait
4. Laura J. den Hartigh
5. Haiming Cao
6. G. Hotamışlıgil

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. Gerald I. Shulman
4. D. Clegg
5. B. Palmer
6. P. Seale
7. C. R. Kahn
8. Jun Wu

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. J. Kirkland
5. T. Tchkonia
6. D. Clegg
7. B. Palmer
8. Jun Wu

Citations in the corpus

• Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications (2007, background): “Removal of intra-abdominal AT in rodents ameliorates DIO-associated insulin resistance (26) and prevents insulin resistance and glucose intolerance of aging (25).”
• Fat Tissue, Aging, and Cellular Senescence (2010, background): “Removing intra-abdominal fat reduces insulin resistance more profoundly than removing subcutane- ous fat from rodents (Barzilai et al., 1999; Weber et al., 2000; Gabriely et al., 2002; Huffman & Barzilai, 2009).”
• Caloric restriction. (2011, background): “These data indicated a key role played by VF in the etiology of age related insulin resistance which could be reversed because of the disproportionate effects of CR on VF (Barzilai and Gupta, 1999; Gabriely et al., 2002a).”
• Beneficial effects of subcutaneous fat transplantation on metabolism. (2008, background): “As in humans, omentectomy in obese mice results in improved insulin action and reduced hepatic glucose production (Gabriely et al., 2002).”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “The removal of visceral fat from Zucker diabetic fatty rats resulted in dramatic reductions in systemic cytokines (544); this suggests that removing visceral fat, rather than the subcutaneous fat that is routinely removed during liposuction, is more advantageous in terms of resolving inflammation.”
• The sexual dimorphism of obesity (2015, positive): “Surgical removal of visceral adipose tissues in animals and humans improves insulin resistance and diabetes (Gabriely et al., 2002).”
• Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch (2014, background): “The functional importance of these adipose depots has been directly demonstrated in studies showing metabolic benefit by transplantation of SubQ fat or surgical removal of VISC fat (Gabriely et al., 2002; Tran et al., 2008).”
• The role of estrogens in control of energy balance and glucose homeostasis. (2013, background): “However, in male rodents, surgical removal of visceral adipose tissue prevents insulin resistance and glucose intolerance (125).”