Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications

By K. Strissel, Zlatina S. Stancheva, H. Miyoshi, J. Perfield, Jason Defuria, Zoe Jick, A. Greenberg, M. Obin. Diabetes, 2007

927 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2beb420170ed59993fc662ef2edc621f2e9bf0bf

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Citations in the corpus

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth (2009, result): “In the tissue growth model, we included the recruitment of new cells and the growth of existing cells, but not the death of old cells, because the model was consistent with the data without the apoptosis of adipose cells. This result is also consistent with a study observing that epididymal fat tiss”
Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “Accordingly, in obese mouse models, the epididymal fat exhibits much greater rates of adipocyte death/tissue remodeling as reflected in an increased number of macrophages forming crown like structures (CLS) around dead adipocytes (Strissel et al. 2007;Nishimura et al. 2008).”
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, unknown): “These macrophages surround the dead adipocytes, forming what is described histologically as “crown-like structures” (62–64).”
Adipocytokines in Obesity and Metabolic Disease (2014, unknown): “Adiponectin enhances the clearance of apoptotic cells by facilitating their opsoniza- tion and uptake by macrophages (Takemura et al. 2007).”
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Notably, these trichrome-positive streaks are distinct from the previously described “crown-like structures” that are characteristic of necrotic adipocytes surrounded by macrophages (44).”
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Most of the recruited ATMs in obese adipose tissues are present near perilipin-negative adipocytes, forming CLSs (80, 81).”
Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis (2009, background): “Further validation, through identification of candidate adipose tissue epitopes, would imply autoimmunity in obesity, where VAT selective adipocyte death has, in fact, already been describe”