Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

By S. Bauer, C. Kirschning, Hans Häcker, V. Redecke, S. Hausmann, Shizuo Akira, H. Wagner, G. Lipford. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,690 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/9629e8cf17a4186709c37828f48edfae66a39aee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. K. Takeda
5. B. Beutler
6. Yong‐jun Liu
7. T. Kaisho
8. M. Gilliet

In Microbiology

1. Shizuo Akira
2. R. Medzhitov
3. K. Takeda
4. Yong‐jun Liu
5. B. Beutler
6. T. Kaisho
7. M. Gilliet
8. A. Krieg

Citations in the corpus

• Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 (2002, background): “In earlier studies we and others demonstrated by using semiquantitative RT-PCR that PDC express TLR9, while monocytes expressed TLR2 and TLR4 (6, 9).”
• Therapeutic potential of Toll-like receptor 9 activation (2006, background): “Once TLR9 was identified as the CpG receptor, it was possible to show that the species-specific recognition was present at the level of the TLR9 itsel”
• Toll-like receptors: critical proteins linking innate and acquired immunity (2001, background): “Although there are few published reports on the expression of TLRs on each subset, TLR4 and TLR9 are expressed on monocyte-derived DCs (MDDCs) and plasmacytoid DCs (pDC2s), respectivel”
• siRNA vs. shRNA: similarities and differences. (2009, background): “Viral vectors are popular for laboratory delivery of shRNA because of their high transfection efficiency and effective integration of exogenous DNA, but they have been losing support in recent years because of concerns over safety and immunogenicity [137,138].”
• How we detect microbes and respond to them: the Toll‐like receptors and their transducers (2003, background): “TLR9 with regard to DNA binding [35] and for TLR2 with”
• Toll-like receptors. (2003, background): “When mouse or human TLR9 was expressed in the CpG DNAunresponsive cell line 293, these cells gained the ability to respond to the optimal mouse or human CpG sequence, respectively (133).”
• War and peace at mucosal surfaces (2004, background): “TLRs sense extracellular PAMPs and trigger 'outside in' signalling that leads to the activation of pro-inflammatory pathway”
• Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8 (2005, positive): “Transient transfections were performed as previously described with some modifications (24).”