Toll-like receptors: critical proteins linking innate and acquired immunity

By Shizuo Akira, K. Takeda, T. Kaisho. Nature Immunology, 2001

5,090 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/af22ab3cc99c0cc01d8b7be23f8c897465a90bb6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Shizuo Akira
2. K. Takeda
3. Luke A. O'Neill
4. R. Medzhitov
5. Taro Kawai
6. B. Beutler
7. Satoshi Uematsu
8. G. Barton

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. O. Takeuchi
5. K. Takeda
6. Satoshi Uematsu
7. Luke A. O'Neill
8. B. Beutler

In Microbiology

1. Shizuo Akira
2. K. Takeda
3. R. Medzhitov
4. Satoshi Uematsu
5. Taro Kawai
6. O. Takeuchi
7. J. Hoffmann
8. B. Lemaître

Citations in the corpus

• Dendritic-cell control of pathogen-driven T-cell polarization (2003, background): “Adaptive immunity to pathogens often starts with the initiation of DC maturation after ligation of TLRs, which, therefore, are crucial proteins that link innate and adaptive immunit”
• Targeting natural killer cells and natural killer T cells in cancer (2012, background): “A recent paradigm shift in our understanding of immunity in mammals has resulted from the discovery of the recognition receptors used by the innate immune system, including the Toll-like receptors (TLRs”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “A major advance in this field has been the elucidation of the TLRs, which are activated by recognition of pathogenassociated molecular patterns (PAMPs) (6).”
• TLR signaling pathways. (2004, background): “In addition, recent accumulating evidence indicates that TLR signaling pathways consist, at least, of a MyD88-dependent pathway that is common to all TLRs, and a MyD88-independent pathway that is peculiar to the TLR3- and TLR4 signaling pathways [8].”
• TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction (2003, background): “Ten members of the TLR family (TLR1–10) have been identified in human”
• Interaction between the gut microbiome and mucosal immune system (2017, background): “TLRs are a group of important PRRs play a vital role in the innate immune system [40].”
• NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses (2004, background): “PGN is recognized independently of its MDP or iE-DAP components by cell surface Toll-like receptor 2 (TLR2), and cells that lack TLR2 are refractory to PGN stimulation and fail to show PGN-induced cytokine secretio”