Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

By S. Katsuma, A. Hirasawa, G. Tsujimoto. Biochemical and Biophysical Research Communications - BBRC, 2005

765 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Oncology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/95eb24e569b462bfba021909300bb095e9ca1545

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. J. Y. Chiang
2. Bart Staels

In Oncology

1. J. Y. Chiang
2. P. Edwards
3. Johan Auwerx
4. David S. Wishart

In Pediatrics, Perinatology and Child Health

1. J. Y. Chiang

Citations in the corpus

• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, neutral): “Katsuma et al. (2005) first”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “In addition, in vitro studies demonstrated that BAs promote GLP-1 secretion through the activation of TGR5 in the murine enteroendocrine STC-1 cell line (143).”
• Gut microbiota functions: metabolism of nutrients and other food components (2017, background): “Through binding to these receptors, bile acids can regulate genes critical to their synthesis, conjugation, transport, and detoxification [75–77] as well as lipid [78, 79] and glucose metabolism [80, 81] and energy homeostasis [82].”
• TGR5-mediated bile acid sensing controls glucose homeostasis. (2009, background): “, 2006), and inspired by the fact that TGR5 is expressed in enteroendocrine cells (Katsuma et al., 2005; Reimann et al., 2008), we explored in this study whether TGR5 activation could alter glucose homeostasis.”
• Bile acids: regulation of synthesis (2009, background): “stimulates glucagon-like peptide 1 (GLP-1) (39), which has anti-diabetic activity.”
• Bile Acid Metabolism and Signaling (2013, neutral): “Knockdown of TGR5 mRNA expression by siRNA GLP-1 secretion suggesting that bile acids induce GLP-1 secretion by TGR5-dependent cAMP production (95).”
• Pleiotropic Roles of Bile Acids in Metabolism (2013, background): “It is hypothesized that GLP-1 then binds to the GLP-1 receptor in the liver, leading to the improved insulin sensitivity (Katsuma et al., 2005; Keitel and Häussinger, 2012; Thomas et al., 2009).”