Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection

By Alan C. Mullen, Frances A. High, Anne S. Hutchins, Hubert W. Lee, A. Villarino, D. Livingston, A. Kung, N. Cereb, T. Yao, S. Yang and 1 more. Science, 2001

990 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/95ea4fb5b6d85e28c1d51c07f14863ace910f7f1

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In Immunology

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Citations in the corpus

• T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells (2002, neutral): “However, another study placed T-bet expression before IL-12 and STAT4 in T H 1 developmen”
• Decision making in the immune system: The lineage decisions of helper T cells (2002, positive): “, inducing both transcriptional competence of the locus encoding IFN-γ and selective responsiveness to the growth factor IL-12 (Ref”
• Development and maintenance of regulatory T cells. (2013, background): “For example, in Tconv cells, STAT1 activation by IFN-g induces the expression of T-bet, which in turn drives expression of the IL-12 receptor component IL-12Rb2 (Afkarian et al., 2002; Mullen et al., 2001).”
• T Cell-Intrinsic Requirement for NF-κB Induction in Postdifferentiation IFN-γ Production and Clonal Expansion in a Th1 Response1 (2003, background): “The T-box transcription factor T-bet is critical for the emergence of a differentiated Th1 population in vitro and in vivo, and induction of this protein is promoted by Stat4 (10, 11).”
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages (2005, background): “STAT1 signaling induces expression of T-bet, which is critical for T H 1 cell development through its actions promoting IL-12Rβ2 expression, among other potential effect”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “Ramos HJ, Davis AM, George TC, Farrar JD. IFN-α is not sufficient to drive Th1 development due to lack of stable T-bet expression.”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “This massive T cell proliferation is critical to long-term immunity because the magnitude of the initial clonal burst typically determines memory T cell numbers (Hou et al., 1994; Murali-Krishna et al., 1998).”
• The role of Th1/Th2 polarization in mucosal immunity (2002, background): “, and points potentially towards a more general role of T-bet in Th1 T-cell differentiation, perhaps via induction of IL-12 receptor β2 chain expression and chromatin remodelin”
• The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease (2002, result): “Recent studies from Reiner and colleagues further reveal that T-bet controls Th1 effector fate by regulating IL-12 2 chain expression and directing chromatin remodeling to individual IFN- alleles (55).”
• Interleukin-12 and the regulation of innate resistance and adaptive immunity (2003, result): “Although IL-12 was reported originally to induce expression of T-bet, more-recent studies have shown that T-bet is induced in T cells even when IL-12 is blocked or in STAT4-deficient mic”
• T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “Additionally, stable T-bet expression and full commitment to the T H 1 lineage depends on signaling by IL-12 through its cognate recepto”