T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

By M. Afkarian, J. Šedý, Jianfei Yang, N. G. Jacobson, N. Cereb, S. Yang, T. Murphy, K. Murphy. Nature Immunology, 2002

1,168 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/5b394b15b51ebcfc775dafe5bf2a68faab4fd5d9

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In Immunology

1. Jinfang Zhu
2. W. E. Paul
3. Jian-Xin Lin
4. W. Liao
5. W. Leonard
6. Dan R. Littman
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In Oncology

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Citations in the corpus

• Development and maintenance of regulatory T cells. (2013, background): “For example, in Tconv cells, STAT1 activation by IFN-g induces the expression of T-bet, which in turn drives expression of the IL-12 receptor component IL-12Rb2 (Afkarian et al., 2002; Mullen et al., 2001).”
• Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “Interleukin-12 (IL-12), acting via the signal transducer and activator of transcription 4 (Stat4), initiates the development of Th1 cells that produce the signature cytokine interferon-g (IFN-g) and express the key regulator T-box 21 (Tbx21, also called T-bet) (Afkarian et al., 2002; Kaplan et al., ”
• Plasticity of CD4+ T cell lineage differentiation. (2009, background): “IL-12Rb2 induction is dependent on T-bet activation through IFN-g and Stat1 signaling (Mullen et al., 2001; Afkarian et al., 2002).”
• Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “…is essential for driving Th1 cell differentiation and inducing T-bet, promoting the survival andproliferation of Th1 cells, a transcriptionally permissive chromatin structure at the Ifng locus, and enhanced IL-12Rb2 expression (Afkarian et al., 2002; Szabo et al., 2003; Zhang and Boothby, 2006).”
• GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4‐independent IFNγ production in T cells (2004, methodology): “To measure the expression of IFNg at earlier time points in primary cells, we used an intracellular staining method as described by Afkarian et al (2002).”
• Regulation of IFN-γ Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-γ Receptor1 (2005, background): “T-bet is a master regulator of Th1 development and not only controls IFN- /IFN- R-induced Th1 development, but also up-regulates expression of the IL-12R 2 chain and allows T cells to become responsive to IL-12 (24, 30).”
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “Importantly, Eomes expression by NK cells chain (Afkarian et al., 2002; Szabo et al., 2000, 2002).”