Adult‐born hippocampal neurons mature into activity‐dependent responsiveness

By Sebastian Jessberger, Gerd Kempermann. 2003

339 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Neurology

Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Using BrdU to birth-date adult-born DGCs, it was found that neuronal activity (whether at physiological or aberrant levels) does not induce IEG expression in adult-born DGCs until they reach a certain stage of maturation — around 3–4 weeks of age in mic”
A Critical Time Window for the Recruitment of Bulbar Newborn Neurons by Olfactory Discrimination Learning (2011, methodology): “Recruitment of newborn neurons by odor stimulation By imaging the activation of 2-, 5-, and 9-week-old neurons using a classical functional anatomical approach (Jessberger and Kempermann, 2003; Ramirez-Amaya et al., 2006; Kee et al., 2007; Tashiro et al., 2007; Trouche et al., 2009), we found that o”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, positive): “Immunohistochemistry was performed as described previously (Jessberger and Kempermann 2003).”
Neurogenesis in the Adult Hippocampus. (2015, background): “The behavioral and pharmacological induction of immediate early gene expression in new neurons has revealed an increasing responsivess to synaptic stimulation that parallels the maturation of adult-born cells (Jessberger and Kempermann 2003).”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “Although 1- to 3-week-old neurons have lower thresholds for induction of long-term potentiation, they do not display activity-dependent expression of immediate early genes at this stage (Jessberger and Kempermann, 2003).”
Seizures Accelerate Functional Integration of Adult-Generated Granule Cells (2006, positive): “, 2005) and seizure-induced c-Fos activation (Jessberger and Kempermann, 2003).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, positive): “Perfusion and preparation of brain sections were described previously (40).”
Integration of New Neurons into Functional Neural Networks (2006, background): “Although mature, new granule cells have been shown previously to express cFos after spatial learning (Jessberger and Kempermann, 2003), cFos expression has not yet been related directly to neural activity, nor is cFos a specific marker for neurons (Arenander et al., 1989).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Glutamatergic inputs through NMDA receptors are critical for the survival of immature neurons [14], and surviving neurons are functionally integrated into existing circuits within 1 month [17].”
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory (2009, background): “They start receiving glutamatergic synaptic inputs, are able to fire action potentials (35, 36), and undergo cytoskeletal reorganization that may enable synaptic tagging (37).”
A hypothesis about the role of adult neurogenesis in hippocampal function. (2004, background): “Additional indirect evidence for functional neurogenesis was provided by labeling newly generated neurons in the DG with BrdU and a transsynaptic neuronal tracer (3) or colabeling with BrdU, neuronal markers, and immediate early genes used as indicators of neuronal activity (14).”
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling (2007, methodology): “Detecting c-fos in newborn neurons after synaptic activation has been used to study the responsiveness of newborn neurons in the adult hippocampus (Jessberger and Kempermann, 2003; Kee et al., 2007; Tashiro et al., 2007).”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, positive): “ference in activation (Jessberger and Kempermann, 2003; Tashiro et al., 2007) of new cells relative to older cells.”
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, background): “Evidence also shows that they can express a learning-induced immediate–early gene response (Jessberger & Kempermann, 2003).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, methodology): “Immunofluorescent triple labeling was done as described previously (Jessberger and Kempermann, 2003).”