Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling

By Sebastian Jessberger, Chunmei Zhao, N. Toni, Gregory D. Clemenson, Yan Li, Fred H. Gage. 2007

365 citations recorded by the source corpus.

Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience

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In Cell Biology

Fred H. Gage

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, neutral): “, causes morphological abnormalities in adult-born DGC”
Adult generation of glutamatergic olfactory bulb interneurons (2009, methodology): “Detection of c-fos has previously been used to demonstrate the integration of newborn neurons in the adult dentate gyru”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “Seizure activity also leads to mossy fiber sprouting of neurons born prior to seizure activity (Jessberger et al., 2007; Walter et al., 2007).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “, 2007) or toward the hilus after epileptic seizures (Scharfman et al., 2003; Jessberger et al., 2007; Kron et al., 2010) indicates that newborn DGCs do have the potential to migrate further”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “Aberrations in hippocampal neurogenesis have been implicated in epileptic seizures (Jessberger et al., 2007), Alzheimer disease (Tatebayashi et al.”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, neutral): “For example, neuronal activation through seizures accelerates the tempo of adult neurogenesis (Overstreet-Wadiche et al., 2006), and prolonged seizures induce inappropriate integration of new neurons into the adult hippocampal circuitry (Jessberger et al., 2007).”
The Developmental Stage of Dentate Granule Cells Dictates Their Contribution to Seizure-Induced Plasticity (2010, methodology): “The proportion of 2006) and that altered neurogenesis after SE is long lasting, with ectopic cells forming for many months after seizure induction (Rao et al., 2006; Jessberger et al., 2007).”