A hypothesis about the role of adult neurogenesis in hippocampal function.

By A. F. Schinder, Fred H. Gage. 2004

126 citations recorded by the source corpus.

The functional relevance of adult hippocampal neurogenesis has long been a matter of intense experimentation and debate, but the precise role of new neurons has not been sufficiently elaborated. Here we propose a hypothesis in which specific features of newly generated neurons contribute to hippocampal plasticity and function and discuss the most recent and relevant findings in the context of the proposed hypothesis.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, positive): “Computational models of adult-born DGC function As adult neurogenesis has become more widely appreciated as an important form of hippocampal plasticity, its potential to affect learning and memory has been increasingly recognize”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “…adult hippocampus continuously generates new neurons to provide the preexisting network with functional properties that are required for information processing in the hippocampus, but are absent in all other cells of the layer generated during development (Schinder & Gage, 2004; Ming & Song, 2005).”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “It is now widely recognized that adult neurogenesis can affect the expression of plasticity in this area (Schinder and Gage, 2004).”
Potential role for adult neurogenesis in the encoding of time in new memories (2006, background): “Whereas these functions are plausible implications of replacing neurons in this circuit, the increasing evidence suggesting that these new neurons are not functionally identical to the existing granule cells during their development has additional implications for their function within the dentate g”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “Adult hippocampal neurogenesis has been observed in vertebrates from birds to humans (Nottebohm, 2002), yet its physiological significance remains essentially unknown (Schinder and Gage, 2004).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “A number of hypotheses have been developed to explain how new neurons might contribute to hippocampal function (Schinder and Gage 2004; Becker 2005; Aimone et al. 2006; Kempermann 2008).”
Structural Plasticity and Hippocampal Function (2010, background): “In this context, new neurons would provide more synapses for learning and added processing abilities (Schinder & Gage 2004).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “However, the functional significance of adult neurogenesis remains unclear (Kempermann, 2002; Schinder and Gage, 2004).”