Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

By A. Cerwenka, Alexander B. H. Bakker, Terri McClanahan, J. Wagner, Jun Wu, J. H. Phillips, Lewis L. Lanier. Immunity, 2000

778 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/94ac71ec10dd39e79d1b18d757e3688acd23bfd3

How researchers see this paper

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In Immunology

1. Robert Schreiber
2. G. Dunn
3. Zena Werb
4. D. Raulet
5. Lloyd J. Old
6. A. Steinle
7. I. Waldhauer
8. É. Vivier

In Oncology

1. Robert Schreiber
2. Zena Werb
3. G. Dunn
4. Lloyd J. Old
5. Hugo Gonzalez
6. A. Steinle
7. M. Colonna
8. D. Raulet

Citations in the corpus

• NK cells and cancer immunosurveillance (2008, background): “In vivo experiments assessing a functional role of NKG2DL for tumour surveillance demonstrated that ectopic expression of Rae1b and H60 conferred a strong immunostimulatory capacity to otherwise tumour-forming malignant cell lines (Cerwenka et al., 2001; Diefenbach et al., 2001).”
• Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells (2001, background): “These include the putative human ULBP proteins and their possible murine counterparts, the retinoic acid early-inducible 1 (Rae-1) family of ligand”
• Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (2002, background): “In the mouse, which lacks MHC class I chain (MIC) genes, a family of proteins structurally related to ULBP, the retinoic acidearly (RAE-1) molecules function as ligands for NKG2D (13, 14).”
• Roles of the NKG2D immunoreceptor and its ligands (2003, background): “Expression of putative ligands expressed by various mouse tumour-cell lines was observed, and cDNAs encoding the ligands were subsequently clone”
• Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “Besides NKG2D, NK cells have a repertoire of different stimulatory cell surface receptors, which, upon binding to their tumor-derived ligands, activate NK cells (Cerwenka et al. 2000; Diefenbach et al. 2000, 2001; Raulet 2003).”
• Immune functions encoded by the natural killer gene complex (2003, background): “NKG2D is expressed as a disulphide-linked homodimer by NKT cells, γδ T cells, CD8 + T cells and macrophage”
• Cancer immunoediting: from immunosurveillance to tumor escape (2002, background): “Structures on the transformed cells (either expressed as a result of the transformation process itself or induced by the ongoing but limited inflammatory response) are recognized by infiltrating lymphocytes such as NKT, NK or γδ T cells, which are then stimulated to produce IFN-&gamma”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “However, lymphoma cell lines RMA and RMA-S, and melanoma cell line B16F10 lack expression of NKG2D ligands (37).”
• The role of the NKG2D immunoreceptor in immune cell activation and natural killing. (2002, neutral): “(Bauer et al., 1999; Cerwenka et al., 2000; Diefenbach et al., 2000, 2001).”