Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

By V. Groh, R. Rhinehart, J. Randolph-Habecker, M. Topp, S. Riddell, T. Spies. Nature Immunology, 2001

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Regulation of ligands for the NKG2D activating receptor (2013, background): “In conventional CD8+ T cells, NKG2D may also provide costimulatory function (16, 17), although this is most evident for the subset of highly activated CD8+ T cells that lacks expression of CD28, the conventional costimulatory receptor for T cells (16).”
Natural killer cells, viruses and cancer (2001, background): “A role for NKG2D in the co-stimulation of CD8+ T cells during HCMV recognition was recently shown by Groh et al.66.”
The role of the NKG2D immunoreceptor in immune cell activation and natural killing. (2002, neutral): “(Groh et al., 2001).”
Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (2002, background): “Engagement of NKG2D by MICA expressed on transfectants and tumor cell lines triggers NK cells and V 1 T cells and costimulates CD8 T cells (4, 8, 9).”