Reactive oxygen species in cell signaling.

By V. Thannickal, B. Fanburg. American Journal of Physiology - Lung cellular and Molecular Physiology, 2000

2,873 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/94890d2f063c7e135838290899ffd9d8bb544381

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Citations in the corpus

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling (2009, background): “In particular, ROS are a well known activator of NF B, AP-1, MAPK, and PI3K pathways (29).”
Oxygen, oxidative stress, hypoxia, and heart failure. (2005, background): “and TNF-α, for example, can induce H2O2 and O2•– formation via activation of the NAD(P)H oxidases (10, 15).”
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “pathways, cellular redox systems and mechanisms of apoptosis [19–23].”
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. (2005, background): “Many nonphagocytic cell types, however, are now known to produce H2O2 in response to a variety of extracellular stimuli such as cytokines, neurotransmitters, peptide growth factors and hormones [2–5].”
Cellular response to oxidative stress: Signaling for suicide and survival * (2002, background): “ROS encompass a variety of partially reduced metabolites of oxygen (e.g., superoxide anions, hydrogen peroxide, and hydroxyl radicals) possessing higher reactivities than molecular oxygen (reviewed in Thannickal and Fanburg, 2000).”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “OH is defined as the most potent oxidizing species of biological membrane proteins and lipids and has an extremely short half life (150, 374, 413).”
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. (2005, positive): “ROS are known to be involved in a number of signaling pathways (Thannickal and Fanburg, 2000) that potentially modulate hydroxylase activity.”
Role of oxygen radicals in DNA damage and cancer incidence (2004, background): “If a phagocytic cell such as the neutrophil is exposed to a stimulus, it has the ability of recognizing the foreign particle and undergoing a series of reactions called the respiratory burst [29].”
Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins (2015, positive): “36), which successfully reduced ROS levels during LAP (Supplementary Fig.”