neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.

By G. Gradwohl, A. Dierich, M. Lemeur, F. Guillemot. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,515 citations recorded by the source corpus.

Subfields: Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/945cfee1e88636a8809d8e2e7f6a34ce635392e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. J. Belmonte
2. Lori Sussel
3. Stéphanie Boué
4. C. Jopling

In Surgery

1. C. Wright
2. F. C. Pan
3. Guoqiang Gu
4. Jolanta Dubauskaite
5. D. Melton
6. Lori Sussel

Citations in the corpus

• Opposing actions of Arx and Pax4 in endocrine pancreas development. (2003, background): “5 pancreas were first incubated with antisera against -galactosidase together with antisera against the Pax6, Ngn3, or Isl1 proteins (Ahlgren et al. 1997; Sander et al. 1997; Gradwohl et al. 2000).”
• β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas (2008, background): “, 1995), and Ngn3 is an essential master switch for differentiation of embryonic islet cell progenitors (Apelqvist et al., 1999; Gradwohl et al., 2000; Gu et al., 2002; Schwitzgebel et al., 2000) and extremely rare in normal postnatal pancreas (Gu et al.”
• Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. (2000, background): “In contrast, animals lacking neurogenin3 fail to express neuroD1 (Gradwohl et al., 2000), suggesting that the role of neurogenin3 may be to activate neuroD1, which in turn directs endocrine cell differentiation, similar to the proposed role of neurogenins Fig.”
• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, background): “The Ngn3knockout phenotype is particularly interesting in that exocrine tissue and pancreatic ducts are nearly normal, but differentiated endocrine cells (islets) are absent (Gradwohl et al., 2000).”
• Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. (2000, background): “Nevertheless, colocalization of PDX1 and glucagon early in development has been detected (Guz et al., 1995).”
• A bipotential precursor population for pancreas and liver within the embryonic endoderm. (2001, background): “, 1996), Pdx1-positive cells give rise to Isl1- and ngn3-positive cells as progenitors of the endocrine lineage (Ahlgren et al., 1997; Gradwohl et al., 2000) and to p48-positive cells as progenitors of the exocrine lineage (Krapp et al.”
• Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells (2006, background): “In the embryo, NGN3 is expressed in endocrine progenitor”
• Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “This is followed by a transient expression of Ngn3 , which initiates β-cell differentiatio”
• The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, positive): “4A) (Krapp et al., 1998; Gradwohl et al., 2000; Kawaguchi et al., 2002).”
• Pancreas organogenesis: From bud to plexus to gland (2011, background): “from within the trunk epithelium, their nascent formation being marked by transient high levels of the pro-endocrine TF Neurogenin3 (Ngn3) (Gradwohl et al., 2000; Schwitzgebel et al., 2000; Jensen et al., 2000a; Gu et al., 2002).”