Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
By V. Schwitzgebel, David W. Scheel, Jennifer R. Conners, J. Kalamaras, Jacqueline E. Lee, David J. Anderson, Lori Sussel, Jeffrey D. Johnson, M. German. Development, 2000
721 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/5b563a75ac99d31d0d4edec04f880fe627e05f08
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Citations in the corpus
- Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, background): “Consistent with the finding that Ngn3 expression is transient (Jensen et al., 2000; Schwitzgebel et al., 2000), our analysis of NGN3+ progenitors demonstrates that individual NGN3+ cells do not maintain Ngn3expression during embryogenesis from which we conclude that NGN3+ cells in early embryos…”
- Pancreas organogenesis: From bud to plexus to gland (2011, background): “5 in most cells of the nascent pancreatic buds, and is essential for pancreas organogenesis in mouse and human (Kawaguchi et al., 2002; Krapp et al., 1998; Sellick et al., 2004).”
- FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (2005, background): “This protein is expressed in uncommitted pancreatic endocrine precursor cells and then becomes restricted to differentiated β cells, where it promotes Ins2 expression (Jensen et al., 2000; Schwitzgebel et al., 2000).”
- Opposing actions of Arx and Pax4 in endocrine pancreas development. (2003, background): “1, Pdx1, and Pax4) and the late factors (Brn4, Isl1, and Pax6) present in mature endocrine cells that are devoid of Ngn3 expression (Jensen et al. 2000; Schwitzgebel et al. 2000).”
- Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells (2006, background): “In the embryo, NGN3 is expressed in endocrine progenitor”
- β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas (2008, background): “, 1995), and Ngn3 is an essential master switch for differentiation of embryonic islet cell progenitors (Apelqvist et al., 1999; Gradwohl et al., 2000; Gu et al., 2002; Schwitzgebel et al., 2000) and extremely rare in normal postnatal pancreas (Gu et al.”