A bipotential precursor population for pancreas and liver within the embryonic endoderm.

By G. Deutsch, Joo-Un Jung, Minghua Zheng, J. Lora, K. Zaret. Development, 2001

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Organogenesis and development of the liver. (2010, background): “Moreover, FGF-mediated specification of hepatic cell fate is concentration dependent and this appears to be controlled by the position of the endoderm relative to the heart, which is the major source of hepatogenic FGF (Deutsch et al., 2001; Serls et al., 2005).”
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, unknown): “…populations of pancreas cells have been previously established and typically include factors such as EGF, HGF and Nicotinamide (Bonner-Weir et al , 2000; Ramiya et al , 2000; Deutsch et al , 2001; Seaberg et al , 2004; Rovira et al , 2010; Cardinale et al , 2011; Smukler et al , 2011).”
Pancreas organogenesis: From bud to plexus to gland (2011, background): “Instead, pancreas fate is initiated, and has raised the perhaps debatable conclusion that the ‘‘default fate’’ of ventral foregut endoderm is pancreas (Deutsch et al., 2001).”
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. (2001, background): “We had noted previously that such explants usually contained fibroblastic cells, but the function of these cells was unknown (Gualdi et al. 1996; Jung et al. 1999b; Deutsch et al. 2001).”