Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

By K. D’Amour, Bang An, Susan Eliazer, Olivia G. Kelly, A. Agulnick, Nora G. Smart, M. Moorman, Evert J Kroon, M. Carpenter, E. Baetge. Nature Biotechnology, 2006

1,973 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/c5af2356da76bd2b1a8c96259b58b296b4bea45f

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In Molecular Biology

1. Hans Clevers
2. Charles E. Murry
3. Toshiro Sato
4. M. van de Wetering
5. H. Begthel
6. J. van Es
7. R. Vries
8. Meritxell Huch

In Surgery

1. Hans Clevers
2. G. Keller
3. D. Melton
4. Charles E. Murry
5. Nikolaos G. Frangogiannis

Citations in the corpus

• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “ESCs and iPSCs can be differentiated towards beta cells in vitro (D’Amour et al , 2006; Zhang et al , 2009; Nostro et al , 2011; Cheng et al , 2012) and in vivo (Soria et al , 2000; Kroon et al , 2008; Sneddon et al , 2012), but the reproducibility of such procedures has been limited (Lysy et al ,…”
• Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, methodology): “Although the cells are represented as aggregates, the initial protocol was carried out in monolayer cultures (D’Amour et al., 2006).”
• Generation of functional human pancreatic β cells in vitro (2014, background): “…pancreatic progenitors (PP2) could be further differentiated in vitro into some INS+ cells along with INS+/GCG+ or INS+/SST+ polyhormonal (PH) cells (Nostro et al., 2011; Rezania et al., 2012; Thowfeequ et al., 2007; Aguayo-Mazzucato et al., 2013; D’Amour et al., 2006; Hrvatin et al., 2014).”