Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.

By P. Herrera. Development, 2000

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Pancreatic β-Cell Dedifferentiation As Mechanism Of Diabetic β-Cell Failure (2012, unknown): “Mice Ins2-cre (Herrera, 2000), Rosa26-eGfp (Gu et al.”
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, methodology): “Pdx1 expressing progenitors give rise to all three types of pancreatic tissue Previous lineage tracing showed that Pdx1-expressing cells give rise to mature α and β cells in adult mice (Herrera, 2000), but that study did not determine whether PDX1+ cells also gave rise to other pancreatic cell types”
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors (2002, methodology): “Moreover, although lineage-tracing techniques have been used to study the inter-relationships in the pancreatic endocrine cell lineag”
Opposing actions of Arx and Pax4 in endocrine pancreas development. (2003, methodology): “By irreversibly tagging the progeny of cells via the Cre/ LoxP system, Herrera (2000) clearly demonstrated that adult glucagon- and insulin-producing cells do not derive from cells that coexpressed both hormones previously, but rather emerge through distinct pathways.”